Fabrication and assembly of multi-layered microstructures embedding cells inside microfluidic devices

Tao Yue, Masahiro Nakajima, Huaping Wang, Chengzhi Hu, Masaru Takeuchi, Toshio Fukuda

科研成果: 书/报告/会议事项章节会议稿件同行评审

1 引用 (Scopus)

摘要

Recently the research about constructing 3 dimensional cell structures is very important for its great potential applications in tissue engineering. In this paper, we report a novel method of constructing multi-layered microstructures embedding cells via microfluidic devices. The on-chip fabrication of movable microstructures embedding fibroblasts (NIH/3T3) based on Poly (ethylene glycol) Diacrylate (PEGDA) was reported. Two approaches for assembling these movable microstructures were presented. One was a manual assembly method based on micromanipulation system and the other one was a self-assembly method based on microfluidic channel. Several manual assembly ways were demonstrated and a tube-shaped microstructure with 17 layers was assembled by an efficient assembly method. A novel microfluidic channel was presented for conducting self-assembly method and a 2-layered experimental microfluidic device was fabricated by Polydimethylsiloxane (PDMS). The self-assembly process of fabricated microstructures via this device was preliminarily demonstrated.

源语言英语
主期刊名IROS 2013
主期刊副标题New Horizon, Conference Digest - 2013 IEEE/RSJ International Conference on Intelligent Robots and Systems
514-519
页数6
DOI
出版状态已出版 - 2013
活动2013 26th IEEE/RSJ International Conference on Intelligent Robots and Systems: New Horizon, IROS 2013 - Tokyo, 日本
期限: 3 11月 20138 11月 2013

出版系列

姓名IEEE International Conference on Intelligent Robots and Systems
ISSN(印刷版)2153-0858
ISSN(电子版)2153-0866

会议

会议2013 26th IEEE/RSJ International Conference on Intelligent Robots and Systems: New Horizon, IROS 2013
国家/地区日本
Tokyo
时期3/11/138/11/13

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引用此

Yue, T., Nakajima, M., Wang, H., Hu, C., Takeuchi, M., & Fukuda, T. (2013). Fabrication and assembly of multi-layered microstructures embedding cells inside microfluidic devices. 在 IROS 2013: New Horizon, Conference Digest - 2013 IEEE/RSJ International Conference on Intelligent Robots and Systems (页码 514-519). 文章 6696400 (IEEE International Conference on Intelligent Robots and Systems). https://doi.org/10.1109/IROS.2013.6696400