Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis

Qi Li; Zhen Wang; Vy M. Dong; Xiao Hui Yang

doi:10.1021/jacs.2c12779

Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis

Qi Li, Zhen Wang, Vy M. Dong^*, Xiao Hui Yang^*

^*此作品的通讯作者

前沿交叉科学研究院

科研成果: 期刊稿件 › 文章 › 同行评审

27 引用（Scopus）

摘要

As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.

源语言	英语
期刊	Journal of the American Chemical Society
DOI	https://doi.org/10.1021/jacs.2c12779
出版状态	已接受/待刊 - 2022

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abstract = "As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.",

author = "Qi Li and Zhen Wang and Dong, {Vy M.} and Yang, {Xiao Hui}",

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AU - Li, Qi

AU - Wang, Zhen

AU - Dong, Vy M.

AU - Yang, Xiao Hui

PY - 2022

Y1 - 2022

N2 - As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.

AB - As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.

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DO - 10.1021/jacs.2c12779

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Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis

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