Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis

Qi Li; Zhen Wang; Vy M. Dong; Xiao Hui Yang

doi:10.1021/jacs.2c12779

Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis

Qi Li, Zhen Wang, Vy M. Dong^*, Xiao Hui Yang^*

^*Corresponding author for this work

Advanced Research Institute of Multidisciplinary Science

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.

Original language	English
Journal	Journal of the American Chemical Society
DOIs	https://doi.org/10.1021/jacs.2c12779
Publication status	Accepted/In press - 2022

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10.1021/jacs.2c12779

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title = "Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis",

abstract = "As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.",

author = "Qi Li and Zhen Wang and Dong, {Vy M.} and Yang, {Xiao Hui}",

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AU - Li, Qi

AU - Wang, Zhen

AU - Dong, Vy M.

AU - Yang, Xiao Hui

PY - 2022

Y1 - 2022

N2 - As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.

AB - As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.

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U2 - 10.1021/jacs.2c12779

DO - 10.1021/jacs.2c12779

M3 - Article

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SN - 0002-7863

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

ER -

Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis

Abstract

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