Li, Y., Lin, T. Y., Luo, Y., Liu, Q., Xiao, W., Guo, W., Lac, D., Zhang, H., Feng, C., Wachsmann-Hogiu, S., Walton, J. H., Cherry, S. R., Rowland, D. J., Kukis, D., Pan, C., & Lam, K. S. (2014). A smart and versatile theranostic nanomedicine platform based on nanoporphyrin. Nature Communications, 5, 文章 4712. https://doi.org/10.1038/ncomms5712
Li, Yuanpei ; Lin, Tzu Yin ; Luo, Yan 等. / A smart and versatile theranostic nanomedicine platform based on nanoporphyrin. 在: Nature Communications. 2014 ; 卷 5.
@article{3243cf0827894496bc715925376812e1,
title = "A smart and versatile theranostic nanomedicine platform based on nanoporphyrin",
abstract = "Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart 'all-in-one' nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumour detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumours. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumours for photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs or therapeutic radio-metals into tumours.",
author = "Yuanpei Li and Lin, {Tzu Yin} and Yan Luo and Qiangqiang Liu and Wenwu Xiao and Wenchang Guo and Diana Lac and Hongyong Zhang and Caihong Feng and Sebastian Wachsmann-Hogiu and Walton, {Jeffrey H.} and Cherry, {Simon R.} and Rowland, {Douglas J.} and David Kukis and Chongxian Pan and Lam, {Kit S.}",
year = "2014",
month = aug,
day = "26",
doi = "10.1038/ncomms5712",
language = "English",
volume = "5",
journal = "Nature Communications",
issn = "2041-1723",
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Li, Y, Lin, TY, Luo, Y, Liu, Q, Xiao, W, Guo, W, Lac, D, Zhang, H, Feng, C, Wachsmann-Hogiu, S, Walton, JH, Cherry, SR, Rowland, DJ, Kukis, D, Pan, C & Lam, KS 2014, 'A smart and versatile theranostic nanomedicine platform based on nanoporphyrin', Nature Communications, 卷 5, 4712. https://doi.org/10.1038/ncomms5712
A smart and versatile theranostic nanomedicine platform based on nanoporphyrin. / Li, Yuanpei; Lin, Tzu Yin; Luo, Yan 等.
在:
Nature Communications, 卷 5, 4712, 26.08.2014.
科研成果: 期刊稿件 › 文章 › 同行评审
TY - JOUR
T1 - A smart and versatile theranostic nanomedicine platform based on nanoporphyrin
AU - Li, Yuanpei
AU - Lin, Tzu Yin
AU - Luo, Yan
AU - Liu, Qiangqiang
AU - Xiao, Wenwu
AU - Guo, Wenchang
AU - Lac, Diana
AU - Zhang, Hongyong
AU - Feng, Caihong
AU - Wachsmann-Hogiu, Sebastian
AU - Walton, Jeffrey H.
AU - Cherry, Simon R.
AU - Rowland, Douglas J.
AU - Kukis, David
AU - Pan, Chongxian
AU - Lam, Kit S.
PY - 2014/8/26
Y1 - 2014/8/26
N2 - Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart 'all-in-one' nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumour detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumours. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumours for photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs or therapeutic radio-metals into tumours.
AB - Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart 'all-in-one' nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumour detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumours. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumours for photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs or therapeutic radio-metals into tumours.
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SN - 2041-1723
VL - 5
JO - Nature Communications
JF - Nature Communications
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Li Y, Lin TY, Luo Y, Liu Q, Xiao W, Guo W 等. A smart and versatile theranostic nanomedicine platform based on nanoporphyrin. Nature Communications. 2014 8月 26;5:4712. doi: 10.1038/ncomms5712
