A smart and versatile theranostic nanomedicine platform based on nanoporphyrin

Yuanpei Li; Tzu Yin Lin; Yan Luo; Qiangqiang Liu; Wenwu Xiao; Wenchang Guo; Diana Lac; Hongyong Zhang; Caihong Feng; Sebastian Wachsmann-Hogiu; Jeffrey H. Walton; Simon R. Cherry; Douglas J. Rowland; David Kukis; Chongxian Pan; Kit S. Lam

doi:10.1038/ncomms5712

A smart and versatile theranostic nanomedicine platform based on nanoporphyrin

Yuanpei Li^*, Tzu Yin Lin, Yan Luo, Qiangqiang Liu, Wenwu Xiao, Wenchang Guo, Diana Lac, Hongyong Zhang, Caihong Feng, Sebastian Wachsmann-Hogiu, Jeffrey H. Walton, Simon R. Cherry, Douglas J. Rowland, David Kukis, Chongxian Pan, Kit S. Lam

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

375 Citations (Scopus)

Abstract

Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart 'all-in-one' nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumour detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumours. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumours for photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs or therapeutic radio-metals into tumours.

Original language	English
Article number	4712
Journal	Nature Communications
Volume	5
DOIs	https://doi.org/10.1038/ncomms5712
Publication status	Published - 26 Aug 2014

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abstract = "Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart 'all-in-one' nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumour detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumours. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumours for photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs or therapeutic radio-metals into tumours.",

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AU - Lin, Tzu Yin

AU - Luo, Yan

AU - Liu, Qiangqiang

AU - Xiao, Wenwu

AU - Guo, Wenchang

AU - Lac, Diana

AU - Zhang, Hongyong

AU - Feng, Caihong

AU - Wachsmann-Hogiu, Sebastian

AU - Walton, Jeffrey H.

AU - Cherry, Simon R.

AU - Rowland, Douglas J.

AU - Kukis, David

AU - Pan, Chongxian

AU - Lam, Kit S.

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AB - Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart 'all-in-one' nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumour detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumours. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumours for photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs or therapeutic radio-metals into tumours.

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A smart and versatile theranostic nanomedicine platform based on nanoporphyrin

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