“Turn-On” Fluorescent Biosensors for High Selective and Sensitive Detection of Al3+ Ion

Pengfei Wang; Lijie Liu; Fanda Meng; Maroof Ahmad Khan; Hui Li

doi:10.3389/fchem.2020.607614

“Turn-On” Fluorescent Biosensors for High Selective and Sensitive Detection of Al³⁺ Ion

Pengfei Wang, Lijie Liu, Fanda Meng, Maroof Ahmad Khan, Hui Li^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A series of new compounds (1-4) based on pyrrole hydrazone Schiff bases were designed and synthesized. The interactions of these new compounds with metal ions and their fluorescent recognition were investigated. All compounds showed “turn-on” fluorescence in the presence of Al³⁺ in aqueous solution. Their sensing behaviors with Al³⁺ were studied using photophysical experiments, ESI-MS spectrometry analysis, ¹H NMR titration, and DFT calculation. The detection limits of 1-4 for the analysis of Al³⁺ were found to reach a 10⁻⁸ M level in aqueous solution, which are far lower than the WHO guidelines for drinking water (7.41 mM for Al³⁺). A high selectivity test paper has been fabricated for Al³⁺ detection based on sensor 3. Theoretical calculations (DFT) have been carried out to elucidate the configuration of 1-4 and their Al complexes and rationalize experimental absorption data.

Original language	English
Article number	607614
Journal	Frontiers in Chemistry
Volume	8
DOIs	https://doi.org/10.3389/fchem.2020.607614
Publication status	Published - 19 Nov 2020

Keywords

detection of Al
fluorescent biosensors
pyrrole hydrazone Schiff base
test paper
theoretical calculation

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10.3389/fchem.2020.607614

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title = "“Turn-On” Fluorescent Biosensors for High Selective and Sensitive Detection of Al3+ Ion",

abstract = "A series of new compounds (1-4) based on pyrrole hydrazone Schiff bases were designed and synthesized. The interactions of these new compounds with metal ions and their fluorescent recognition were investigated. All compounds showed “turn-on” fluorescence in the presence of Al3+ in aqueous solution. Their sensing behaviors with Al3+ were studied using photophysical experiments, ESI-MS spectrometry analysis, 1H NMR titration, and DFT calculation. The detection limits of 1-4 for the analysis of Al3+ were found to reach a 10−8 M level in aqueous solution, which are far lower than the WHO guidelines for drinking water (7.41 mM for Al3+). A high selectivity test paper has been fabricated for Al3+ detection based on sensor 3. Theoretical calculations (DFT) have been carried out to elucidate the configuration of 1-4 and their Al complexes and rationalize experimental absorption data.",

keywords = "detection of Al, fluorescent biosensors, pyrrole hydrazone Schiff base, test paper, theoretical calculation",

author = "Pengfei Wang and Lijie Liu and Fanda Meng and Khan, {Maroof Ahmad} and Hui Li",

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doi = "10.3389/fchem.2020.607614",

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AU - Wang, Pengfei

AU - Liu, Lijie

AU - Meng, Fanda

AU - Khan, Maroof Ahmad

AU - Li, Hui

PY - 2020/11/19

Y1 - 2020/11/19

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AB - A series of new compounds (1-4) based on pyrrole hydrazone Schiff bases were designed and synthesized. The interactions of these new compounds with metal ions and their fluorescent recognition were investigated. All compounds showed “turn-on” fluorescence in the presence of Al3+ in aqueous solution. Their sensing behaviors with Al3+ were studied using photophysical experiments, ESI-MS spectrometry analysis, 1H NMR titration, and DFT calculation. The detection limits of 1-4 for the analysis of Al3+ were found to reach a 10−8 M level in aqueous solution, which are far lower than the WHO guidelines for drinking water (7.41 mM for Al3+). A high selectivity test paper has been fabricated for Al3+ detection based on sensor 3. Theoretical calculations (DFT) have been carried out to elucidate the configuration of 1-4 and their Al complexes and rationalize experimental absorption data.

KW - detection of Al

KW - fluorescent biosensors

KW - pyrrole hydrazone Schiff base

KW - test paper

KW - theoretical calculation

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“Turn-On” Fluorescent Biosensors for High Selective and Sensitive Detection of Al³⁺ Ion

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Keywords

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