The enantioselective trifluoromethylation of aromatic aldehydes by quaternary ammonium bromide and (IPr)CuF at low catalyst loading

Shaoxiang Wu; Jiyi Guo; Muhammad Sohail; Chengyao Cao; Fu Xue Chen

doi:10.1016/j.jfluchem.2013.01.027

The enantioselective trifluoromethylation of aromatic aldehydes by quaternary ammonium bromide and (IPr)CuF at low catalyst loading

Shaoxiang Wu, Jiyi Guo, Muhammad Sohail, Chengyao Cao, Fu Xue Chen^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

A general catalytic enantioselective trifluoromethylation of aromatic aldehydes using (IPr)CuF and quinidine-derived quaternary ammonium salt as catalysts has been developed. A wide range of aromatic aldehydes are converted to the corresponding products in up to 92% yield and 81% ee at 2 mol% of catalyst loading.

Original language	English
Pages (from-to)	19-29
Number of pages	11
Journal	Journal of Fluorine Chemistry
Volume	148
DOIs	https://doi.org/10.1016/j.jfluchem.2013.01.027
Publication status	Published - Apr 2013

Keywords

Aldehyde
Asymmetric catalysis
Carbene copper species
Quaternary ammonium salt
Trifluoromethylation

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10.1016/j.jfluchem.2013.01.027

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title = "The enantioselective trifluoromethylation of aromatic aldehydes by quaternary ammonium bromide and (IPr)CuF at low catalyst loading",

abstract = "A general catalytic enantioselective trifluoromethylation of aromatic aldehydes using (IPr)CuF and quinidine-derived quaternary ammonium salt as catalysts has been developed. A wide range of aromatic aldehydes are converted to the corresponding products in up to 92% yield and 81% ee at 2 mol% of catalyst loading.",

keywords = "Aldehyde, Asymmetric catalysis, Carbene copper species, Quaternary ammonium salt, Trifluoromethylation",

author = "Shaoxiang Wu and Jiyi Guo and Muhammad Sohail and Chengyao Cao and Chen, {Fu Xue}",

year = "2013",

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doi = "10.1016/j.jfluchem.2013.01.027",

language = "English",

volume = "148",

pages = "19--29",

journal = "Journal of Fluorine Chemistry",

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AU - Wu, Shaoxiang

AU - Guo, Jiyi

AU - Sohail, Muhammad

AU - Cao, Chengyao

AU - Chen, Fu Xue

PY - 2013/4

Y1 - 2013/4

N2 - A general catalytic enantioselective trifluoromethylation of aromatic aldehydes using (IPr)CuF and quinidine-derived quaternary ammonium salt as catalysts has been developed. A wide range of aromatic aldehydes are converted to the corresponding products in up to 92% yield and 81% ee at 2 mol% of catalyst loading.

AB - A general catalytic enantioselective trifluoromethylation of aromatic aldehydes using (IPr)CuF and quinidine-derived quaternary ammonium salt as catalysts has been developed. A wide range of aromatic aldehydes are converted to the corresponding products in up to 92% yield and 81% ee at 2 mol% of catalyst loading.

KW - Aldehyde

KW - Asymmetric catalysis

KW - Carbene copper species

KW - Quaternary ammonium salt

KW - Trifluoromethylation

UR - http://www.scopus.com/inward/record.url?scp=84874035103&partnerID=8YFLogxK

U2 - 10.1016/j.jfluchem.2013.01.027

DO - 10.1016/j.jfluchem.2013.01.027

M3 - Article

AN - SCOPUS:84874035103

SN - 0022-1139

VL - 148

SP - 19

EP - 29

JO - Journal of Fluorine Chemistry

JF - Journal of Fluorine Chemistry

ER -

The enantioselective trifluoromethylation of aromatic aldehydes by quaternary ammonium bromide and (IPr)CuF at low catalyst loading

Abstract

Keywords

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