Surface plasmon resonance sensor combining with molecularly imprinted film for progesterone detection

Qing Wen Zhang; Ya Min Ren; Tian Xin Wei

doi:10.15918/j.tbit1001-0645.2015.02.019

Surface plasmon resonance sensor combining with molecularly imprinted film for progesterone detection

Qing Wen Zhang, Ya Min Ren, Tian Xin Wei^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A surface plasmon resonance (SPR) sensor based on molecularly imprinted film (MIF) was proposed for the sensitive detection of progesterone. The MIF was synthesized by the method of thermo and photo polymerization on the sensor surface, which was subsequently removed to form the recognition cavities by the mixture of acetonitrile and acetic acid. The SPR sensor develops the angle shift by 1.15° (thermo polymerization) and 0.72° (photo polymerization) after washing progesterone from MIF and allowed detection of progesterone at concentration down to 10^-14 g/mL. The resonance angle changes show a good linearity versus minus logarithmic concentration of progesterone from 10^-14 g/mL to 10^-6 g/mL. A control experiment with the analogues estradiol, testosterone and testosterone propionate (10^-4 g/mL) shows a good selectivity of the MIF for the recognition of progesterone.

Original language	English
Pages (from-to)	208-212
Number of pages	5
Journal	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume	35
Issue number	2
DOIs	https://doi.org/10.15918/j.tbit1001-0645.2015.02.019
Publication status	Published - 1 Feb 2015

Keywords

Molecularly imprinted film (MIF)
Progesterone
Surface plasmon resonance (SPR)

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Zhang, Q. W., Ren, Y. M., & Wei, T. X. (2015). Surface plasmon resonance sensor combining with molecularly imprinted film for progesterone detection. Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology, 35(2), 208-212. https://doi.org/10.15918/j.tbit1001-0645.2015.02.019

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abstract = "A surface plasmon resonance (SPR) sensor based on molecularly imprinted film (MIF) was proposed for the sensitive detection of progesterone. The MIF was synthesized by the method of thermo and photo polymerization on the sensor surface, which was subsequently removed to form the recognition cavities by the mixture of acetonitrile and acetic acid. The SPR sensor develops the angle shift by 1.15° (thermo polymerization) and 0.72° (photo polymerization) after washing progesterone from MIF and allowed detection of progesterone at concentration down to 10-14 g/mL. The resonance angle changes show a good linearity versus minus logarithmic concentration of progesterone from 10-14 g/mL to 10-6 g/mL. A control experiment with the analogues estradiol, testosterone and testosterone propionate (10-4 g/mL) shows a good selectivity of the MIF for the recognition of progesterone.",

keywords = "Molecularly imprinted film (MIF), Progesterone, Surface plasmon resonance (SPR)",

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AB - A surface plasmon resonance (SPR) sensor based on molecularly imprinted film (MIF) was proposed for the sensitive detection of progesterone. The MIF was synthesized by the method of thermo and photo polymerization on the sensor surface, which was subsequently removed to form the recognition cavities by the mixture of acetonitrile and acetic acid. The SPR sensor develops the angle shift by 1.15° (thermo polymerization) and 0.72° (photo polymerization) after washing progesterone from MIF and allowed detection of progesterone at concentration down to 10-14 g/mL. The resonance angle changes show a good linearity versus minus logarithmic concentration of progesterone from 10-14 g/mL to 10-6 g/mL. A control experiment with the analogues estradiol, testosterone and testosterone propionate (10-4 g/mL) shows a good selectivity of the MIF for the recognition of progesterone.

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Surface plasmon resonance sensor combining with molecularly imprinted film for progesterone detection

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Keywords

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