Study on HPCE enantiomeric separation of two drug racemates

Fang Li; Hui Jin; Junling Gu; Ruonong Fu; Rongji Dai

Study on HPCE enantiomeric separation of two drug racemates

Fang Li^*, Hui Jin, Junling Gu, Ruonong Fu, Rongji Dai

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

It was reported for the first time that the racemic ofloxacin and 2-amino-N-isobutyl-l-phenylethanol enantiomers were separated by HPCE. The effects of the important experimental parameters such as the concentration of the chiral selector and pH of the background electrolyte on the separations were investigated. And the baseline separation of enantiomers of ofloxacin and 2-amino-N-isobutyl-1-phenylethanol was finally achieved with CZE using 2, 6-dimethyl-β-CD as the chiral selector.

Original language	English
Pages (from-to)	166-169
Number of pages	4
Journal	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume	17
Issue number	2
Publication status	Published - 1997

Keywords

Cyclodextrins
Enantiomers
Enantioseparation
HPCE

Cite this

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title = "Study on HPCE enantiomeric separation of two drug racemates",

abstract = "It was reported for the first time that the racemic ofloxacin and 2-amino-N-isobutyl-l-phenylethanol enantiomers were separated by HPCE. The effects of the important experimental parameters such as the concentration of the chiral selector and pH of the background electrolyte on the separations were investigated. And the baseline separation of enantiomers of ofloxacin and 2-amino-N-isobutyl-1-phenylethanol was finally achieved with CZE using 2, 6-dimethyl-β-CD as the chiral selector.",

keywords = "Cyclodextrins, Enantiomers, Enantioseparation, HPCE",

author = "Fang Li and Hui Jin and Junling Gu and Ruonong Fu and Rongji Dai",

year = "1997",

language = "English",

volume = "17",

pages = "166--169",

journal = "Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology",

issn = "1001-0645",

publisher = "Beijing Institute of Technology",

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TY - JOUR

T1 - Study on HPCE enantiomeric separation of two drug racemates

AU - Li, Fang

AU - Jin, Hui

AU - Gu, Junling

AU - Fu, Ruonong

AU - Dai, Rongji

PY - 1997

Y1 - 1997

N2 - It was reported for the first time that the racemic ofloxacin and 2-amino-N-isobutyl-l-phenylethanol enantiomers were separated by HPCE. The effects of the important experimental parameters such as the concentration of the chiral selector and pH of the background electrolyte on the separations were investigated. And the baseline separation of enantiomers of ofloxacin and 2-amino-N-isobutyl-1-phenylethanol was finally achieved with CZE using 2, 6-dimethyl-β-CD as the chiral selector.

AB - It was reported for the first time that the racemic ofloxacin and 2-amino-N-isobutyl-l-phenylethanol enantiomers were separated by HPCE. The effects of the important experimental parameters such as the concentration of the chiral selector and pH of the background electrolyte on the separations were investigated. And the baseline separation of enantiomers of ofloxacin and 2-amino-N-isobutyl-1-phenylethanol was finally achieved with CZE using 2, 6-dimethyl-β-CD as the chiral selector.

KW - Cyclodextrins

KW - Enantiomers

KW - Enantioseparation

KW - HPCE

UR - http://www.scopus.com/inward/record.url?scp=0042184516&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0042184516

SN - 1001-0645

VL - 17

SP - 166

EP - 169

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 2

ER -

Study on HPCE enantiomeric separation of two drug racemates

Abstract

Keywords

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