Studies on the structure and chirality of A-motif in adenosine monophosphate nucleotide metal coordination complexes

Muhammad Javed Iqbal; Zhongkui Li; Maroof Ahmad Khan; Yanhong Zhu; Wajid Hussain; Hao Su; Qi Ming Qiu; Rizwan Shoukat; Hui Li

doi:10.1039/d1ce00276g

Studies on the structure and chirality of A-motif in adenosine monophosphate nucleotide metal coordination complexes

Muhammad Javed Iqbal, Zhongkui Li, Maroof Ahmad Khan, Yanhong Zhu, Wajid Hussain, Hao Su, Qi Ming Qiu, Rizwan Shoukat, Hui Li^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Nucleotide constructs B-DNA and non-B DNA. Non-B DNA leads to the genetic instability, genetic diseases and rearrangement of bases. The adenine-adenine base pair mismatch (A-motif) is considered to be the origin of some types of diseases unknown to humanity. One of the stumbling blocks in the study of the mismatched base pairs is short of the structural evidences or details, which arises from the difficulties of crystallizing the nucleotide compounds. Towards this aim, we have designed and constructed three 1D coordination polymers, namely {[Cd(bpe)(HdAMP)₂(H₂O)₂]·(bpe)·(CH₃OH)·4H₂O}_n(1), {[Mn(bpe)(HdAMP)₂(H₂O)₂]·(bpe)·8H₂O}_n(2) and {[Cd(AMP)(bpe)(H₂O)₃]·7H₂O}_n(3). All of them have been characterized structurallyviasingle crystal X-ray diffraction. The complexes1and2have A-motif structures, while the complex3does not have the A-motif structure. The intermolecular recognition and interactions for the construction of A-motif have been described according to the comprehensive analysis of single crystal structures. It is a rare report on A-motif single crystals in the field of nucleotide coordination polymers. Moreover, the chiralities of the three complexes have been investigated by the combination of single crystal structure and solid-state chiral dichroism (CD) spectroscopy. In this study, for the first time, the novel supramolecular chirality of extending axial chirality (EAC) has been confirmed by complex3as an excellent example, and complexes1and2as a counterexample.

Original language	English
Pages (from-to)	4175-4180
Number of pages	6
Journal	CrystEngComm
Volume	23
Issue number	23
DOIs	https://doi.org/10.1039/d1ce00276g
Publication status	Published - 21 Jun 2021

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Iqbal, M. J., Li, Z., Khan, M. A., Zhu, Y., Hussain, W., Su, H., Qiu, Q. M., Shoukat, R., & Li, H. (2021). Studies on the structure and chirality of A-motif in adenosine monophosphate nucleotide metal coordination complexes. CrystEngComm, 23(23), 4175-4180. https://doi.org/10.1039/d1ce00276g

@article{254efe03e6f74f23b4f447adc20e6a62,

title = "Studies on the structure and chirality of A-motif in adenosine monophosphate nucleotide metal coordination complexes",

abstract = "Nucleotide constructs B-DNA and non-B DNA. Non-B DNA leads to the genetic instability, genetic diseases and rearrangement of bases. The adenine-adenine base pair mismatch (A-motif) is considered to be the origin of some types of diseases unknown to humanity. One of the stumbling blocks in the study of the mismatched base pairs is short of the structural evidences or details, which arises from the difficulties of crystallizing the nucleotide compounds. Towards this aim, we have designed and constructed three 1D coordination polymers, namely {[Cd(bpe)(HdAMP)2(H2O)2]·(bpe)·(CH3OH)·4H2O}n(1), {[Mn(bpe)(HdAMP)2(H2O)2]·(bpe)·8H2O}n(2) and {[Cd(AMP)(bpe)(H2O)3]·7H2O}n(3). All of them have been characterized structurallyviasingle crystal X-ray diffraction. The complexes1and2have A-motif structures, while the complex3does not have the A-motif structure. The intermolecular recognition and interactions for the construction of A-motif have been described according to the comprehensive analysis of single crystal structures. It is a rare report on A-motif single crystals in the field of nucleotide coordination polymers. Moreover, the chiralities of the three complexes have been investigated by the combination of single crystal structure and solid-state chiral dichroism (CD) spectroscopy. In this study, for the first time, the novel supramolecular chirality of extending axial chirality (EAC) has been confirmed by complex3as an excellent example, and complexes1and2as a counterexample.",

author = "Iqbal, {Muhammad Javed} and Zhongkui Li and Khan, {Maroof Ahmad} and Yanhong Zhu and Wajid Hussain and Hao Su and Qiu, {Qi Ming} and Rizwan Shoukat and Hui Li",

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year = "2021",

month = jun,

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doi = "10.1039/d1ce00276g",

language = "English",

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T1 - Studies on the structure and chirality of A-motif in adenosine monophosphate nucleotide metal coordination complexes

AU - Iqbal, Muhammad Javed

AU - Li, Zhongkui

AU - Khan, Maroof Ahmad

AU - Zhu, Yanhong

AU - Hussain, Wajid

AU - Su, Hao

AU - Qiu, Qi Ming

AU - Shoukat, Rizwan

AU - Li, Hui

PY - 2021/6/21

Y1 - 2021/6/21

N2 - Nucleotide constructs B-DNA and non-B DNA. Non-B DNA leads to the genetic instability, genetic diseases and rearrangement of bases. The adenine-adenine base pair mismatch (A-motif) is considered to be the origin of some types of diseases unknown to humanity. One of the stumbling blocks in the study of the mismatched base pairs is short of the structural evidences or details, which arises from the difficulties of crystallizing the nucleotide compounds. Towards this aim, we have designed and constructed three 1D coordination polymers, namely {[Cd(bpe)(HdAMP)2(H2O)2]·(bpe)·(CH3OH)·4H2O}n(1), {[Mn(bpe)(HdAMP)2(H2O)2]·(bpe)·8H2O}n(2) and {[Cd(AMP)(bpe)(H2O)3]·7H2O}n(3). All of them have been characterized structurallyviasingle crystal X-ray diffraction. The complexes1and2have A-motif structures, while the complex3does not have the A-motif structure. The intermolecular recognition and interactions for the construction of A-motif have been described according to the comprehensive analysis of single crystal structures. It is a rare report on A-motif single crystals in the field of nucleotide coordination polymers. Moreover, the chiralities of the three complexes have been investigated by the combination of single crystal structure and solid-state chiral dichroism (CD) spectroscopy. In this study, for the first time, the novel supramolecular chirality of extending axial chirality (EAC) has been confirmed by complex3as an excellent example, and complexes1and2as a counterexample.

AB - Nucleotide constructs B-DNA and non-B DNA. Non-B DNA leads to the genetic instability, genetic diseases and rearrangement of bases. The adenine-adenine base pair mismatch (A-motif) is considered to be the origin of some types of diseases unknown to humanity. One of the stumbling blocks in the study of the mismatched base pairs is short of the structural evidences or details, which arises from the difficulties of crystallizing the nucleotide compounds. Towards this aim, we have designed and constructed three 1D coordination polymers, namely {[Cd(bpe)(HdAMP)2(H2O)2]·(bpe)·(CH3OH)·4H2O}n(1), {[Mn(bpe)(HdAMP)2(H2O)2]·(bpe)·8H2O}n(2) and {[Cd(AMP)(bpe)(H2O)3]·7H2O}n(3). All of them have been characterized structurallyviasingle crystal X-ray diffraction. The complexes1and2have A-motif structures, while the complex3does not have the A-motif structure. The intermolecular recognition and interactions for the construction of A-motif have been described according to the comprehensive analysis of single crystal structures. It is a rare report on A-motif single crystals in the field of nucleotide coordination polymers. Moreover, the chiralities of the three complexes have been investigated by the combination of single crystal structure and solid-state chiral dichroism (CD) spectroscopy. In this study, for the first time, the novel supramolecular chirality of extending axial chirality (EAC) has been confirmed by complex3as an excellent example, and complexes1and2as a counterexample.

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U2 - 10.1039/d1ce00276g

DO - 10.1039/d1ce00276g

M3 - Article

AN - SCOPUS:85108002263

SN - 1466-8033

VL - 23

SP - 4175

EP - 4180

JO - CrystEngComm

JF - CrystEngComm

IS - 23

ER -

Studies on the structure and chirality of A-motif in adenosine monophosphate nucleotide metal coordination complexes

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