Squaramide-Catalyzed Asymmetric Reactions

Bo Liang Zhao; Jun Hua Li; Da Ming Du

doi:10.1002/tcr.201600140

Squaramide-Catalyzed Asymmetric Reactions

Bo Liang Zhao, Jun Hua Li, Da Ming Du^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Review article › peer-review

101 Citations (Scopus)

Abstract

Bifunctional squaramides have emerged as powerful hydrogen-bonding catalysts for promoting a wide array of useful asymmetric reactions, which provides convenient methods for the construction of complex molecular structures and chiral biologically active compounds. This review highlights the recent advances of our research group in the chiral squaramide-catalyzed asymmetric reactions, including Michael addition, Mannich reaction, aza-Henry reaction, Strecker reaction as well as cascade or sequential reactions.

Original language	English
Pages (from-to)	994-1018
Number of pages	25
Journal	Chemical Record
Volume	17
Issue number	10
DOIs	https://doi.org/10.1002/tcr.201600140
Publication status	Published - Oct 2017

Keywords

Mannich reaction
Michael addition
asymmetric synthesis
cascade reaction
hydrogen bond
organocatalysis squaramides

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10.1002/tcr.201600140

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Zhao, B. L., Li, J. H., & Du, D. M. (2017). Squaramide-Catalyzed Asymmetric Reactions. Chemical Record, 17(10), 994-1018. https://doi.org/10.1002/tcr.201600140

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title = "Squaramide-Catalyzed Asymmetric Reactions",

abstract = "Bifunctional squaramides have emerged as powerful hydrogen-bonding catalysts for promoting a wide array of useful asymmetric reactions, which provides convenient methods for the construction of complex molecular structures and chiral biologically active compounds. This review highlights the recent advances of our research group in the chiral squaramide-catalyzed asymmetric reactions, including Michael addition, Mannich reaction, aza-Henry reaction, Strecker reaction as well as cascade or sequential reactions.",

keywords = "Mannich reaction, Michael addition, asymmetric synthesis, cascade reaction, hydrogen bond, organocatalysis squaramides",

author = "Zhao, {Bo Liang} and Li, {Jun Hua} and Du, {Da Ming}",

note = "Publisher Copyright: {\textcopyright} 2017 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

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AB - Bifunctional squaramides have emerged as powerful hydrogen-bonding catalysts for promoting a wide array of useful asymmetric reactions, which provides convenient methods for the construction of complex molecular structures and chiral biologically active compounds. This review highlights the recent advances of our research group in the chiral squaramide-catalyzed asymmetric reactions, including Michael addition, Mannich reaction, aza-Henry reaction, Strecker reaction as well as cascade or sequential reactions.

KW - Mannich reaction

KW - Michael addition

KW - asymmetric synthesis

KW - cascade reaction

KW - hydrogen bond

KW - organocatalysis squaramides

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Squaramide-Catalyzed Asymmetric Reactions

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Keywords

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