Abstract
A highly efficient method for the construction of pyrrolidinyl spirooxindoles with 3-isothiocyanato oxindoles and chalcones via a Michael/cyclization cascade reaction has been developed by using bifunctional cinchona-derived squaramide organocatalysts. A series of complex pyrrolidinyl spirooxindoles could be obtained in high yields (up to 99%) with excellent diastereo- and enantioselectivities (up to >99 : 1 dr, >99% ee) under mild conditions.
Original language | English |
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Pages (from-to) | 1229-1238 |
Number of pages | 10 |
Journal | Organic Chemistry Frontiers |
Volume | 4 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 2017 |
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Lin, Y., Liu, L., & Du, D. M. (2017). Squaramide-catalyzed asymmetric Michael/cyclization cascade reaction of 3-isothiocyanato oxindoles with chalcones for synthesis of pyrrolidinyl spirooxindoles. Organic Chemistry Frontiers, 4(7), 1229-1238. https://doi.org/10.1039/c6qo00852f