Reticular Chemistry for Enhancing Bioentity Stability and Functional Performance

Addressing the fragility of bioentities that results in instability and compromised performance during storage and applications, reticular chemistry, specifically through metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), offers versatile platforms for stabilization and enhancement of bioentities. These highly porous frameworks facilitate efficient loading and mass transfer, offer confined environments and selective permeability for stabilization and protection, and enable finely tunable biointerfacial interactions and microenvironments for function optimization, significantly broadening the applications of various bioentities, including enzymes, nucleic acids, cells, etc. This Perspective outlines strategies for integrating bioentities with reticular frameworks, highlighting new design ideas for existing issues within these strategies. It emphasizes the crucial roles of these frameworks for bioentities in enhancing stability, boosting activity, imparting non-native functions, and synergizing bioentity systems. Concluding with a discussion of the challenges and prospects in the design, characterization, and practical applications of these biocomposites, this Perspective aims to inspire further development of high-performance biocomposites in this promising field.