Protein recognition by a surface imprinted colloidal array

Wei Chen; Wen Lei; Min Xue; Fei Xue; Zi Hui Meng; Wei Bing Zhang; Feng Qu; Kenneth J. Shea

doi:10.1039/c4ta00048j

Protein recognition by a surface imprinted colloidal array

Wei Chen, Wen Lei, Min Xue^*, Fei Xue, Zi Hui Meng, Wei Bing Zhang, Feng Qu, Kenneth J. Shea

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

A label-free and easy-to-prepare biosensor for the fast and naked-eye detection of proteins was developed in this study. A closely packed crystalline array was self-assembled in ethanol-water (1 : 1, v/v) from the surface imprinted silica (SIS) colloid for hemoglobin bovine (Hb). The reflection of the molecular imprinted colloidal array (MICA) red shifted by 23 nm in response to 1.0 mg mL^-1 of Hb at pH 7.0. Compared with the non-imprinted colloidal array (NICA), MICA has a higher selectivity towards the target protein, and can recognize the target protein via an "induced-fit" mechanism.

Original language	English
Pages (from-to)	7165-7169
Number of pages	5
Journal	Journal of Materials Chemistry A
Volume	2
Issue number	20
DOIs	https://doi.org/10.1039/c4ta00048j
Publication status	Published - 28 May 2014

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10.1039/c4ta00048j

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AU - Chen, Wei

AU - Lei, Wen

AU - Xue, Min

AU - Xue, Fei

AU - Meng, Zi Hui

AU - Zhang, Wei Bing

AU - Qu, Feng

AU - Shea, Kenneth J.

PY - 2014/5/28

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AB - A label-free and easy-to-prepare biosensor for the fast and naked-eye detection of proteins was developed in this study. A closely packed crystalline array was self-assembled in ethanol-water (1 : 1, v/v) from the surface imprinted silica (SIS) colloid for hemoglobin bovine (Hb). The reflection of the molecular imprinted colloidal array (MICA) red shifted by 23 nm in response to 1.0 mg mL-1 of Hb at pH 7.0. Compared with the non-imprinted colloidal array (NICA), MICA has a higher selectivity towards the target protein, and can recognize the target protein via an "induced-fit" mechanism.

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Protein recognition by a surface imprinted colloidal array

Abstract

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