TY - JOUR
T1 - Photodynamic Therapy-Induced Anti-Tumor Immunity
T2 - Influence Factors and Synergistic Enhancement Strategies
AU - Chou, Wenxin
AU - Sun, Tianzhen
AU - Peng, Nian
AU - Wang, Zixuan
AU - Chen, Defu
AU - Qiu, Haixia
AU - Zhao, Hongyou
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/11
Y1 - 2023/11
N2 - Photodynamic therapy (PDT) is an approved therapeutic procedure that exerts cytotoxic activity towards tumor cells by activating photosensitizers (PSs) with light exposure to produce reactive oxygen species (ROS). Compared to traditional treatment strategies such as surgery, chemotherapy, and radiation therapy, PDT not only kills the primary tumors, but also effectively suppresses metastatic tumors by activating the immune response. However, the anti-tumor immune effects induced by PDT are influenced by several factors, including the localization of PSs in cells, PSs concentration, fluence rate of light, oxygen concentration, and the integrity of immune function. In this review, we systematically summarize the influence factors of anti-tumor immune effects mediated by PDT. Furthermore, an update on the combination of PDT and other immunotherapy strategies are provided. Finally, the future directions and challenges of anti-tumor immunity induced by PDT are discussed.
AB - Photodynamic therapy (PDT) is an approved therapeutic procedure that exerts cytotoxic activity towards tumor cells by activating photosensitizers (PSs) with light exposure to produce reactive oxygen species (ROS). Compared to traditional treatment strategies such as surgery, chemotherapy, and radiation therapy, PDT not only kills the primary tumors, but also effectively suppresses metastatic tumors by activating the immune response. However, the anti-tumor immune effects induced by PDT are influenced by several factors, including the localization of PSs in cells, PSs concentration, fluence rate of light, oxygen concentration, and the integrity of immune function. In this review, we systematically summarize the influence factors of anti-tumor immune effects mediated by PDT. Furthermore, an update on the combination of PDT and other immunotherapy strategies are provided. Finally, the future directions and challenges of anti-tumor immunity induced by PDT are discussed.
KW - combination therapy
KW - influence factors
KW - innate immunity
KW - photodynamic therapy
KW - specific immunity
UR - http://www.scopus.com/inward/record.url?scp=85178339812&partnerID=8YFLogxK
U2 - 10.3390/pharmaceutics15112617
DO - 10.3390/pharmaceutics15112617
M3 - Review article
AN - SCOPUS:85178339812
SN - 1999-4923
VL - 15
JO - Pharmaceutics
JF - Pharmaceutics
IS - 11
M1 - 2617
ER -