Abstract
A one-pot efficient asymmetric domino annulation of 2-isothiocyanato-1-indanones with tert-butyl 2-hydroxybenzylidenecarbamates in situ generated from 2-hydroxyaryl-substituted α-amido sulfones was developed. This reaction firstly provided a powerful tool for the enantioselective construction of functionalized bridged fused ring hererocycles bearing three adjacent stereogenic centers in high yields with excellent diastereo- and enantioselectivities (up to 91% yield, >20 : 1 dr and 99% ee).
Original language | English |
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Pages (from-to) | 4183-4187 |
Number of pages | 5 |
Journal | Organic Chemistry Frontiers |
Volume | 8 |
Issue number | 15 |
DOIs | |
Publication status | Published - 7 Aug 2021 |
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Hou, X. Q., Lin, Y., & Du, D. M. (2021). Organocatalytic domino annulation of: In situ generated tert -butyl 2-hydroxybenzylidenecarbamates with 2-isothiocyanato-1-indanones for synthesis of bridged and fused ring heterocycles. Organic Chemistry Frontiers, 8(15), 4183-4187. https://doi.org/10.1039/d1qo00626f