Near-infrared light-responsive core-shell nanogels for targeted drug delivery

Huaizhi Kang; Anna Carolina Trondoli; Guizhi Zhu; Yan Chen; Ya Jen Chang; Haipeng Liu; Yu Fen Huang; Xiaoling Zhang; Weihong Tan

doi:10.1021/nn201171r

Near-infrared light-responsive core-shell nanogels for targeted drug delivery

Huaizhi Kang, Anna Carolina Trondoli, Guizhi Zhu, Yan Chen, Ya Jen Chang, Haipeng Liu, Yu Fen Huang^*, Xiaoling Zhang, Weihong Tan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

270 Citations (Scopus)

Abstract

A near-infrared light-responsive drug delivery platform based on Au-Ag nanorods (Au-Ag NRs) coated with DNA cross-linked polymeric shells was constructed. DNA complementarity has been applied to develop a polyacrylamide-based sol-gel transition system to encapsulate anticancer drugs into the gel scaffold. The Au-Ag NR-based nanogels can also be readily functionalized with targeting moieties, such as aptamers, for specific recognition of tumor cells. When exposed to NIR irradiation, the photothermal effect of the Au-Ag NRs leads to a rapid rise in the temperature of the surrounding gel, resulting in the fast release of the encapsulated payload with high controllability. In vitro study confirmed that aptamer-functionalized nanogels can be used as drug carriers for targeted drug delivery with remote control capability by NIR light with high spatial/temporal resolution.

Original language	English
Pages (from-to)	5094-5099
Number of pages	6
Journal	ACS Nano
Volume	5
Issue number	6
DOIs	https://doi.org/10.1021/nn201171r
Publication status	Published - 28 Jun 2011
Externally published	Yes

Keywords

DNA cross-linked
light-responsive
nanogels
nanorods
near-infrared
targeted drug delivery

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10.1021/nn201171r

Cite this

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title = "Near-infrared light-responsive core-shell nanogels for targeted drug delivery",

abstract = "A near-infrared light-responsive drug delivery platform based on Au-Ag nanorods (Au-Ag NRs) coated with DNA cross-linked polymeric shells was constructed. DNA complementarity has been applied to develop a polyacrylamide-based sol-gel transition system to encapsulate anticancer drugs into the gel scaffold. The Au-Ag NR-based nanogels can also be readily functionalized with targeting moieties, such as aptamers, for specific recognition of tumor cells. When exposed to NIR irradiation, the photothermal effect of the Au-Ag NRs leads to a rapid rise in the temperature of the surrounding gel, resulting in the fast release of the encapsulated payload with high controllability. In vitro study confirmed that aptamer-functionalized nanogels can be used as drug carriers for targeted drug delivery with remote control capability by NIR light with high spatial/temporal resolution.",

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AU - Kang, Huaizhi

AU - Trondoli, Anna Carolina

AU - Zhu, Guizhi

AU - Chen, Yan

AU - Chang, Ya Jen

AU - Liu, Haipeng

AU - Huang, Yu Fen

AU - Zhang, Xiaoling

AU - Tan, Weihong

PY - 2011/6/28

Y1 - 2011/6/28

N2 - A near-infrared light-responsive drug delivery platform based on Au-Ag nanorods (Au-Ag NRs) coated with DNA cross-linked polymeric shells was constructed. DNA complementarity has been applied to develop a polyacrylamide-based sol-gel transition system to encapsulate anticancer drugs into the gel scaffold. The Au-Ag NR-based nanogels can also be readily functionalized with targeting moieties, such as aptamers, for specific recognition of tumor cells. When exposed to NIR irradiation, the photothermal effect of the Au-Ag NRs leads to a rapid rise in the temperature of the surrounding gel, resulting in the fast release of the encapsulated payload with high controllability. In vitro study confirmed that aptamer-functionalized nanogels can be used as drug carriers for targeted drug delivery with remote control capability by NIR light with high spatial/temporal resolution.

AB - A near-infrared light-responsive drug delivery platform based on Au-Ag nanorods (Au-Ag NRs) coated with DNA cross-linked polymeric shells was constructed. DNA complementarity has been applied to develop a polyacrylamide-based sol-gel transition system to encapsulate anticancer drugs into the gel scaffold. The Au-Ag NR-based nanogels can also be readily functionalized with targeting moieties, such as aptamers, for specific recognition of tumor cells. When exposed to NIR irradiation, the photothermal effect of the Au-Ag NRs leads to a rapid rise in the temperature of the surrounding gel, resulting in the fast release of the encapsulated payload with high controllability. In vitro study confirmed that aptamer-functionalized nanogels can be used as drug carriers for targeted drug delivery with remote control capability by NIR light with high spatial/temporal resolution.

KW - DNA cross-linked

KW - light-responsive

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KW - near-infrared

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Near-infrared light-responsive core-shell nanogels for targeted drug delivery

Abstract

Keywords

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