N-异丙基丙烯酰胺类纳米水凝胶在生物识别中的研究进展

Hydrogel nanoparticles with a three-dimensional network structure of particle size 1~1 000 nm can be stably dispersed in water to form a colloid system. Due to their stimulus responsiveness, they are often referred to as intelligent hydrogel. Among the numerous types of intelligent hydrogel, N-isopropylacrylamide nanohydrogel with thermosensitivity was further studied both on its properties and its application recently. Based on its good biocompatibility, sensitive temperature response and a volume phase change along with the change of external temperature, it was widely applied in biomedical fields such as drug delivery systems, protein separations, medical diagnostics, biosensors, and biomaterials. In this study, the application research and development prospects of N-isopropylacrylamide-based nanohydrogel microspheres in protein recognition, drug delivery and release, and DNA separation were summarized.