TY - JOUR
T1 - Multi-material 3D printed eutectogel microneedle patches integrated with fast customization and tunable drug delivery
AU - Liu, Huan
AU - Zhou, Xinmeng
AU - Nail, Aminov
AU - Yu, Hao
AU - Yu, Zilian
AU - Sun, Yue
AU - Wang, Kun
AU - Bao, Nanbin
AU - Meng, Decheng
AU - Zhu, Liran
AU - Li, Huanjun
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/4
Y1 - 2024/4
N2 - Microneedle patches are emerging multifunctional platforms for transdermal diagnostics and drug delivery. However, it still remains challenging to develop smart microneedles integrated with customization, sensing, detection and drug delivery by 3D printing strategy. Here, we present an innovative but facile strategy to rationally design and fabricate multifunctional eutectogel microneedle (EMN) patches via multi-material 3D printing. Polymerizable deep eutectic solvents (PDES) were selected as printing inks for rapid one-step fabrication of 3D printing functional EMN patches due to fast photopolymerization rate and ultrahigh drug solubility. Moreover, stretchable EMN patches incorporating rigid needles and flexible backing layers were easily realized by changing PDES compositions of multi-material 3D printing. Meanwhile, we developed multifunctional smart multi-material EMN patches capable of performing wireless monitoring of body movements, painless colorimetric glucose detection, and controlled transdermal drug delivery. Thus, such multi-material EMN system could provide an effective platform for the painless diagnosis, detection, and therapy of a variety of diseases.
AB - Microneedle patches are emerging multifunctional platforms for transdermal diagnostics and drug delivery. However, it still remains challenging to develop smart microneedles integrated with customization, sensing, detection and drug delivery by 3D printing strategy. Here, we present an innovative but facile strategy to rationally design and fabricate multifunctional eutectogel microneedle (EMN) patches via multi-material 3D printing. Polymerizable deep eutectic solvents (PDES) were selected as printing inks for rapid one-step fabrication of 3D printing functional EMN patches due to fast photopolymerization rate and ultrahigh drug solubility. Moreover, stretchable EMN patches incorporating rigid needles and flexible backing layers were easily realized by changing PDES compositions of multi-material 3D printing. Meanwhile, we developed multifunctional smart multi-material EMN patches capable of performing wireless monitoring of body movements, painless colorimetric glucose detection, and controlled transdermal drug delivery. Thus, such multi-material EMN system could provide an effective platform for the painless diagnosis, detection, and therapy of a variety of diseases.
KW - 3D printing
KW - Eutectogel
KW - Microneedles
KW - Multi-material
KW - Transdermal drug delivery
UR - http://www.scopus.com/inward/record.url?scp=85185879287&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2024.02.023
DO - 10.1016/j.jconrel.2024.02.023
M3 - Article
C2 - 38367865
AN - SCOPUS:85185879287
SN - 0168-3659
VL - 368
SP - 115
EP - 130
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -