Abstract
An isothiourea-catalysed asymmetric Michael/lactamization cascade reaction of 2-aminobenzothiophenes and α,β-unsaturated anhydrides was developed for the first time. In the presence of a 10 mol% isothiourea catalyst, various benzothienopyridinones were afforded in good to excellent yields (73-96%) with excellent enantioselectivities (up to 98 : 2 er).
Original language | English |
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Pages (from-to) | 5551-5556 |
Number of pages | 6 |
Journal | Organic Chemistry Frontiers |
Volume | 9 |
Issue number | 20 |
DOIs | |
Publication status | Published - 26 Aug 2022 |
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Niu, C., Xie, D. H., & Du, D. M. (2022). Isothiourea-catalysed enantioselective annulation of 2-aminobenzothiophenes with α,β-unsaturated anhydrides. Organic Chemistry Frontiers, 9(20), 5551-5556. https://doi.org/10.1039/d2qo01023b