Isolation and characterization of three fungi with the potential of transforming glycyrrhizin

Chao Wang; Xiao Xiao Guo; Xiao Yan Wang; Feng Qi; Shi Jiang Feng; Chun Li; Xiao Hong Zhou

doi:10.1007/s11274-012-1233-9

Isolation and characterization of three fungi with the potential of transforming glycyrrhizin

Chao Wang, Xiao Xiao Guo, Xiao Yan Wang, Feng Qi, Shi Jiang Feng, Chun Li^*, Xiao Hong Zhou

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Three fungi with different types of transformation of glycyrrhizin (GL) were isolated from the soil samples of glycyrrhiza glabra planting area in China. According to their morphologies and 18 S rDNA gene sequence analysis, the three fungi were identified and named as Penicillium purpurogenum Li-3, Aspergillus terreus Li-20 and Aspergillus ustus Li-62. Transforming products analysis by TLC and HPLC-MS indicated that P. purpurogenum Li-3, A. terreus Li-20 and A. ustus Li-62 could stably transform GL into GAMG, GAMG and GA, and GA, respectively. P. purpurogenum Li-3 was especially valuable to directly prepare GAMG for applications in the pharmaceutical industry.

Original language	English
Pages (from-to)	781-788
Number of pages	8
Journal	World Journal of Microbiology and Biotechnology
Volume	29
Issue number	5
DOIs	https://doi.org/10.1007/s11274-012-1233-9
Publication status	Published - May 2013

Keywords

Biotransformation
Characterization
Fungus
Glycyrrhizin

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10.1007/s11274-012-1233-9

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title = "Isolation and characterization of three fungi with the potential of transforming glycyrrhizin",

abstract = "Three fungi with different types of transformation of glycyrrhizin (GL) were isolated from the soil samples of glycyrrhiza glabra planting area in China. According to their morphologies and 18 S rDNA gene sequence analysis, the three fungi were identified and named as Penicillium purpurogenum Li-3, Aspergillus terreus Li-20 and Aspergillus ustus Li-62. Transforming products analysis by TLC and HPLC-MS indicated that P. purpurogenum Li-3, A. terreus Li-20 and A. ustus Li-62 could stably transform GL into GAMG, GAMG and GA, and GA, respectively. P. purpurogenum Li-3 was especially valuable to directly prepare GAMG for applications in the pharmaceutical industry.",

keywords = "Biotransformation, Characterization, Fungus, Glycyrrhizin",

author = "Chao Wang and Guo, {Xiao Xiao} and Wang, {Xiao Yan} and Feng Qi and Feng, {Shi Jiang} and Chun Li and Zhou, {Xiao Hong}",

year = "2013",

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T1 - Isolation and characterization of three fungi with the potential of transforming glycyrrhizin

AU - Wang, Chao

AU - Guo, Xiao Xiao

AU - Wang, Xiao Yan

AU - Qi, Feng

AU - Feng, Shi Jiang

AU - Li, Chun

AU - Zhou, Xiao Hong

PY - 2013/5

Y1 - 2013/5

N2 - Three fungi with different types of transformation of glycyrrhizin (GL) were isolated from the soil samples of glycyrrhiza glabra planting area in China. According to their morphologies and 18 S rDNA gene sequence analysis, the three fungi were identified and named as Penicillium purpurogenum Li-3, Aspergillus terreus Li-20 and Aspergillus ustus Li-62. Transforming products analysis by TLC and HPLC-MS indicated that P. purpurogenum Li-3, A. terreus Li-20 and A. ustus Li-62 could stably transform GL into GAMG, GAMG and GA, and GA, respectively. P. purpurogenum Li-3 was especially valuable to directly prepare GAMG for applications in the pharmaceutical industry.

AB - Three fungi with different types of transformation of glycyrrhizin (GL) were isolated from the soil samples of glycyrrhiza glabra planting area in China. According to their morphologies and 18 S rDNA gene sequence analysis, the three fungi were identified and named as Penicillium purpurogenum Li-3, Aspergillus terreus Li-20 and Aspergillus ustus Li-62. Transforming products analysis by TLC and HPLC-MS indicated that P. purpurogenum Li-3, A. terreus Li-20 and A. ustus Li-62 could stably transform GL into GAMG, GAMG and GA, and GA, respectively. P. purpurogenum Li-3 was especially valuable to directly prepare GAMG for applications in the pharmaceutical industry.

KW - Biotransformation

KW - Characterization

KW - Fungus

KW - Glycyrrhizin

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Isolation and characterization of three fungi with the potential of transforming glycyrrhizin

Abstract

Keywords

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