Inhibitory effects of different substituted transition metal-based krebs-type sandwich structures on human hepatocellular carcinoma cells

Lu Wang; K. Yu; J. Zhu; B. B. Zhou; J. R. Liu; G. Y. Yang

doi:10.1039/c6dt02420c

Inhibitory effects of different substituted transition metal-based krebs-type sandwich structures on human hepatocellular carcinoma cells

Lu Wang, K. Yu, J. Zhu, B. B. Zhou^*, J. R. Liu, G. Y. Yang

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

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23 Citations (Scopus)

Abstract

Two new transition metal-substituted Krebs-type sandwich structures of (H₂imi)₂[(BiW₉O₃₃)₂{W_0.5Ni_0.5(H₂O)}₂{Na₄ (H₂O)₁₄}{Ni(H₂O)₃}₂]·17.5H₂O (3) and (H₂imi)₂[(BiW₉O₃₃)₂(WO(OH))₂Na₄(H₂O)₁₃(Zn(H₂O)₃)₂]·12H₂O (4) (imi = iminazole) were synthesized using the aqueous solution method, and their structures were identified using elemental analysis, infrared, and ultraviolet spectoscopy, thermogravimetry, and single crystal X-ray diffraction. Two polyoxometalates (POMs) were isomorphic with manganese (Mn²⁺) and cobalt (Co²⁺) compounds, (Himi)₂[(BiW₉O₃₃)₂(W(OH)₂)₂(Mn(H₂O)₃)₂(Na₃(H₂O)₁₄)]·16H₂O (1) and (H₂imi)₂[(BiW₉O₃₃)₂(W(OH)₂)₂(Co(H₂O)₃)₂Na₄ (H₂O)₁₄]·17H₂O (2), which were reported in a previous study. This study continued with the determination of the inhibitory effects of four POMs on human hepatic carcinoma Hep G2 cells. Four compounds were used to compare their effects on the measurement of the sub-G1 (sub-G1 hypodiploid cell population) DNA content, the analysis of nuclear morphology, and the protein expression. The results showed that compound 3 (IC₅₀ = 25.6 ± 1.07 μmol L^-1) had a much higher anti-tumor activity than compounds 1 and 4 in Hep G2 cells. Compound 2 had the lowest anti-tumor activities in Hep G2 cells. However, compound 3 showed much higher cytotoxicity than compounds 1, 2 and 4 in QSG-7701 cells. Compound 4 had the lowest cytotoxicity of all of these compounds. These findings indicate the effective relationship between the metal components and structures, and their antitumor activities in Hep G2 cells.

Original language	English
Pages (from-to)	2874-2883
Number of pages	10
Journal	Dalton Transactions
Volume	46
Issue number	9
DOIs	https://doi.org/10.1039/c6dt02420c
Publication status	Published - 2017

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@article{04d1cefa1dd94eb6ba9323a4d01d1840,

title = "Inhibitory effects of different substituted transition metal-based krebs-type sandwich structures on human hepatocellular carcinoma cells",

abstract = "Two new transition metal-substituted Krebs-type sandwich structures of (H2imi)2[(BiW9O33)2{W0.5Ni0.5(H2O)}2{Na4 (H2O)14}{Ni(H2O)3}2]·17.5H2O (3) and (H2imi)2[(BiW9O33)2(WO(OH))2Na4(H2O)13(Zn(H2O)3)2]·12H2O (4) (imi = iminazole) were synthesized using the aqueous solution method, and their structures were identified using elemental analysis, infrared, and ultraviolet spectoscopy, thermogravimetry, and single crystal X-ray diffraction. Two polyoxometalates (POMs) were isomorphic with manganese (Mn2+) and cobalt (Co2+) compounds, (Himi)2[(BiW9O33)2(W(OH)2)2(Mn(H2O)3)2(Na3(H2O)14)]·16H2O (1) and (H2imi)2[(BiW9O33)2(W(OH)2)2(Co(H2O)3)2Na4 (H2O)14]·17H2O (2), which were reported in a previous study. This study continued with the determination of the inhibitory effects of four POMs on human hepatic carcinoma Hep G2 cells. Four compounds were used to compare their effects on the measurement of the sub-G1 (sub-G1 hypodiploid cell population) DNA content, the analysis of nuclear morphology, and the protein expression. The results showed that compound 3 (IC50 = 25.6 ± 1.07 μmol L-1) had a much higher anti-tumor activity than compounds 1 and 4 in Hep G2 cells. Compound 2 had the lowest anti-tumor activities in Hep G2 cells. However, compound 3 showed much higher cytotoxicity than compounds 1, 2 and 4 in QSG-7701 cells. Compound 4 had the lowest cytotoxicity of all of these compounds. These findings indicate the effective relationship between the metal components and structures, and their antitumor activities in Hep G2 cells.",

author = "Lu Wang and K. Yu and J. Zhu and Zhou, {B. B.} and Liu, {J. R.} and Yang, {G. Y.}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c6dt02420c",

language = "English",

volume = "46",

pages = "2874--2883",

journal = "Dalton Transactions",

issn = "1477-9226",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Inhibitory effects of different substituted transition metal-based krebs-type sandwich structures on human hepatocellular carcinoma cells

AU - Wang, Lu

AU - Yu, K.

AU - Zhu, J.

AU - Zhou, B. B.

AU - Liu, J. R.

AU - Yang, G. Y.

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2017

Y1 - 2017

N2 - Two new transition metal-substituted Krebs-type sandwich structures of (H2imi)2[(BiW9O33)2{W0.5Ni0.5(H2O)}2{Na4 (H2O)14}{Ni(H2O)3}2]·17.5H2O (3) and (H2imi)2[(BiW9O33)2(WO(OH))2Na4(H2O)13(Zn(H2O)3)2]·12H2O (4) (imi = iminazole) were synthesized using the aqueous solution method, and their structures were identified using elemental analysis, infrared, and ultraviolet spectoscopy, thermogravimetry, and single crystal X-ray diffraction. Two polyoxometalates (POMs) were isomorphic with manganese (Mn2+) and cobalt (Co2+) compounds, (Himi)2[(BiW9O33)2(W(OH)2)2(Mn(H2O)3)2(Na3(H2O)14)]·16H2O (1) and (H2imi)2[(BiW9O33)2(W(OH)2)2(Co(H2O)3)2Na4 (H2O)14]·17H2O (2), which were reported in a previous study. This study continued with the determination of the inhibitory effects of four POMs on human hepatic carcinoma Hep G2 cells. Four compounds were used to compare their effects on the measurement of the sub-G1 (sub-G1 hypodiploid cell population) DNA content, the analysis of nuclear morphology, and the protein expression. The results showed that compound 3 (IC50 = 25.6 ± 1.07 μmol L-1) had a much higher anti-tumor activity than compounds 1 and 4 in Hep G2 cells. Compound 2 had the lowest anti-tumor activities in Hep G2 cells. However, compound 3 showed much higher cytotoxicity than compounds 1, 2 and 4 in QSG-7701 cells. Compound 4 had the lowest cytotoxicity of all of these compounds. These findings indicate the effective relationship between the metal components and structures, and their antitumor activities in Hep G2 cells.

AB - Two new transition metal-substituted Krebs-type sandwich structures of (H2imi)2[(BiW9O33)2{W0.5Ni0.5(H2O)}2{Na4 (H2O)14}{Ni(H2O)3}2]·17.5H2O (3) and (H2imi)2[(BiW9O33)2(WO(OH))2Na4(H2O)13(Zn(H2O)3)2]·12H2O (4) (imi = iminazole) were synthesized using the aqueous solution method, and their structures were identified using elemental analysis, infrared, and ultraviolet spectoscopy, thermogravimetry, and single crystal X-ray diffraction. Two polyoxometalates (POMs) were isomorphic with manganese (Mn2+) and cobalt (Co2+) compounds, (Himi)2[(BiW9O33)2(W(OH)2)2(Mn(H2O)3)2(Na3(H2O)14)]·16H2O (1) and (H2imi)2[(BiW9O33)2(W(OH)2)2(Co(H2O)3)2Na4 (H2O)14]·17H2O (2), which were reported in a previous study. This study continued with the determination of the inhibitory effects of four POMs on human hepatic carcinoma Hep G2 cells. Four compounds were used to compare their effects on the measurement of the sub-G1 (sub-G1 hypodiploid cell population) DNA content, the analysis of nuclear morphology, and the protein expression. The results showed that compound 3 (IC50 = 25.6 ± 1.07 μmol L-1) had a much higher anti-tumor activity than compounds 1 and 4 in Hep G2 cells. Compound 2 had the lowest anti-tumor activities in Hep G2 cells. However, compound 3 showed much higher cytotoxicity than compounds 1, 2 and 4 in QSG-7701 cells. Compound 4 had the lowest cytotoxicity of all of these compounds. These findings indicate the effective relationship between the metal components and structures, and their antitumor activities in Hep G2 cells.

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U2 - 10.1039/c6dt02420c

DO - 10.1039/c6dt02420c

M3 - Article

C2 - 28245011

AN - SCOPUS:85014154547

SN - 1477-9226

VL - 46

SP - 2874

EP - 2883

JO - Dalton Transactions

JF - Dalton Transactions

IS - 9

ER -

Inhibitory effects of different substituted transition metal-based krebs-type sandwich structures on human hepatocellular carcinoma cells

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