IB-LBM simulation on blood cell sorting with a micro-fence structure

Qiang Wei, Yuan Qing Xu*, Fang Bao Tian, Tian Xin Gao, Xiao Ying Tang, Wen Hong Zu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

A size-based blood cell sorting model with a micro-fence structure is proposed in the frame of immersed boundary and lattice Boltzmann method (IB-LBM). The fluid dynamics is obtained by solving the discrete lattice Boltzmann equation, and the cells motion and deformation are handled by the immersed boundary method. A micro-fence consists of two parallel slope post rows which are adopted to separate red blood cells (RBCs) from white blood cells (WBCs), in which the cells to be separated are transported one after another by the flow into the passageway between the two post rows. Effected by the cross flow, RBCs are schemed to get through the pores of the nether post row since they are smaller and more deformable compared with WBCs. WBCs are required to move along the nether post row till they get out the micro-fence. Simulation results indicate that for a fix width of pores, the slope angle of the post row plays an important role in cell sorting. The cells mixture can not be separated properly in a small slope angle, while obvious blockages by WBCs will take place to disturb the continuous cell sorting in a big slope angle. As an optimal result, an adaptive slope angle is found to sort RBCs form WBCs correctly and continuously.

Original languageEnglish
Pages (from-to)475-481
Number of pages7
JournalBio-Medical Materials and Engineering
Volume24
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • Blood cell separation
  • Cross flow
  • Lattice Boltzmann method
  • Microfludics
  • immersed Boundary

Fingerprint

Dive into the research topics of 'IB-LBM simulation on blood cell sorting with a micro-fence structure'. Together they form a unique fingerprint.

Cite this