High performance cocktail functional monomer for making molecule imprinting polymer

Zihui Meng; Jinfang Wang; Liangmo Zhou; Qinghai Wang; Daoqian Zhu

doi:10.2116/analsci.15.141

High performance cocktail functional monomer for making molecule imprinting polymer

Zihui Meng^*, Jinfang Wang, Liangmo Zhou, Qinghai Wang, Daoqian Zhu

^*Corresponding author for this work

CAS - Dalian Institute of Chemical Physics

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

In order to make a molecule imprinting polymer (MIP) with highly chiral selectivity against N-t-Boc-L-Trp, a new kind of 'cocktail' functional monomer: acrylamide+2-vinylpyridine was investigated. The MIP showed impressive chiral selectivity (α=3.23). With the increasing of water content in the mobile phase, ionic and hydrophobic interaction were found to be responsible for the chiral recognition process instead of the hydrogen bond. Tailing and peak asymmetry problems were overcome by using linear gradient elution. Physical properties such as thermal stability and pore structure for the MIP were also investigated.

Original language	English
Pages (from-to)	141-144
Number of pages	4
Journal	Analytical Sciences
Volume	15
Issue number	2
DOIs	https://doi.org/10.2116/analsci.15.141
Publication status	Published - Feb 1999
Externally published	Yes

Keywords

Amino acid
Chiral stationary phase
Enantiomer separation
Molecule imprinting

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10.2116/analsci.15.141

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Meng, Z., Wang, J., Zhou, L., Wang, Q., & Zhu, D. (1999). High performance cocktail functional monomer for making molecule imprinting polymer. Analytical Sciences, 15(2), 141-144. https://doi.org/10.2116/analsci.15.141

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abstract = "In order to make a molecule imprinting polymer (MIP) with highly chiral selectivity against N-t-Boc-L-Trp, a new kind of 'cocktail' functional monomer: acrylamide+2-vinylpyridine was investigated. The MIP showed impressive chiral selectivity (α=3.23). With the increasing of water content in the mobile phase, ionic and hydrophobic interaction were found to be responsible for the chiral recognition process instead of the hydrogen bond. Tailing and peak asymmetry problems were overcome by using linear gradient elution. Physical properties such as thermal stability and pore structure for the MIP were also investigated.",

keywords = "Amino acid, Chiral stationary phase, Enantiomer separation, Molecule imprinting",

author = "Zihui Meng and Jinfang Wang and Liangmo Zhou and Qinghai Wang and Daoqian Zhu",

year = "1999",

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doi = "10.2116/analsci.15.141",

language = "English",

volume = "15",

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T1 - High performance cocktail functional monomer for making molecule imprinting polymer

AU - Meng, Zihui

AU - Wang, Jinfang

AU - Zhou, Liangmo

AU - Wang, Qinghai

AU - Zhu, Daoqian

PY - 1999/2

Y1 - 1999/2

N2 - In order to make a molecule imprinting polymer (MIP) with highly chiral selectivity against N-t-Boc-L-Trp, a new kind of 'cocktail' functional monomer: acrylamide+2-vinylpyridine was investigated. The MIP showed impressive chiral selectivity (α=3.23). With the increasing of water content in the mobile phase, ionic and hydrophobic interaction were found to be responsible for the chiral recognition process instead of the hydrogen bond. Tailing and peak asymmetry problems were overcome by using linear gradient elution. Physical properties such as thermal stability and pore structure for the MIP were also investigated.

AB - In order to make a molecule imprinting polymer (MIP) with highly chiral selectivity against N-t-Boc-L-Trp, a new kind of 'cocktail' functional monomer: acrylamide+2-vinylpyridine was investigated. The MIP showed impressive chiral selectivity (α=3.23). With the increasing of water content in the mobile phase, ionic and hydrophobic interaction were found to be responsible for the chiral recognition process instead of the hydrogen bond. Tailing and peak asymmetry problems were overcome by using linear gradient elution. Physical properties such as thermal stability and pore structure for the MIP were also investigated.

KW - Amino acid

KW - Chiral stationary phase

KW - Enantiomer separation

KW - Molecule imprinting

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DO - 10.2116/analsci.15.141

M3 - Article

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SN - 0910-6340

VL - 15

SP - 141

EP - 144

JO - Analytical Sciences

JF - Analytical Sciences

IS - 2

ER -

High performance cocktail functional monomer for making molecule imprinting polymer

Abstract

Keywords

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