FUSION OF VESICLES BY THE GHZ ACOUSTIC STREAMING

Yao Lu, Yang Yang, Xiaotian Shen, Huikai Xie, Xuexin Duan*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this work, we constructed an acoustofluidic system based on a droplet-shaped bulk acoustic wave resonator (BAW) to realize the manipulation of vesicles by three-dimensional acoustic vortex. The acoustic streaming effect generated by the BAW of GHz frequency was enhanced in the microfluidic channel, which induced high-speed vortex and rendered the fusion of two contact vesicles. Giant unilamellar vesicles (GUVs) were used to visualize the trapping and fusion process with a fluorescence microscope. Experiments show that two GUVs separately labelled with two kinds of dyes form a hybrid GUV after fusion in this acoustofluidic system, which can be potentially applied in the field of micro-reactors or used to mimic cellular communications.

Original languageEnglish
Title of host publicationMicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages703-704
Number of pages2
ISBN (Electronic)9781733419048
Publication statusPublished - 2022
Event26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 - Hybrid, Hangzhou, China
Duration: 23 Oct 202227 Oct 2022

Publication series

NameMicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022
Country/TerritoryChina
CityHybrid, Hangzhou
Period23/10/2227/10/22

Keywords

  • Acoustic Vortex
  • Acoustofluidics
  • Bulk Acoustic Wave
  • Vesicle Fusion

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