Niu, G., Zheng, X., Zhao, Z., Zhang, H., Wang, J., He, X., Chen, Y., Shi, X., Ma, C., Kwok, R. T. K., Lam, J. W. Y., Sung, H. H. Y., Williams, I. D., Wong, K. S., Wang, P., & Tang, B. Z. (2019). Functionalized Acrylonitriles with Aggregation-Induced Emission: Structure Tuning by Simple Reaction-Condition Variation, Efficient Red Emission, and Two-Photon Bioimaging. Journal of the American Chemical Society, 141(38), 15111-15120. https://doi.org/10.1021/jacs.9b06196
Niu, Guangle ; Zheng, Xiuli ; Zhao, Zheng et al. / Functionalized Acrylonitriles with Aggregation-Induced Emission : Structure Tuning by Simple Reaction-Condition Variation, Efficient Red Emission, and Two-Photon Bioimaging. In: Journal of the American Chemical Society. 2019 ; Vol. 141, No. 38. pp. 15111-15120.
@article{f750bdf7498f45b29b121f16d7a24687,
title = "Functionalized Acrylonitriles with Aggregation-Induced Emission: Structure Tuning by Simple Reaction-Condition Variation, Efficient Red Emission, and Two-Photon Bioimaging",
abstract = "Acrylonitriles with aggregation-induced emission (AIE) characteristics have been found to show promising applications in two-photon biomedical imaging. Generally, elaborate synthetic efforts are required to achieve different acrylonitriles with distinct functionalities. In this work, we first reported the synthesis of two different group-functionalized AIE-active acrylonitriles (TPAT-AN-XF and 2TPAT-AN) obtained simply by mixing the same reactants at different temperatures using a facile and transition metal-free synthetic method. These two AIE luminogens (AIEgens) exhibit unique properties such as bright red emission in the solid state, large Stokes shift, and large two-photon absorption cross section. Water-soluble nanoparticles (NPs) of 2TPAT-AN were prepared by a nanoprecipitation method. In vitro imaging data show that 2TPAT-AN NPs can selectively stain lysosome in live cells. Besides one-photon imaging, remarkable two-photon imaging of live tumor tissues can be achieved with high resolution and deep tissue penetration. 2TPAT-AN NPs show high biocompatibility and are successfully utilized in in vivo long-term imaging of mouse tumors with a high signal-to-noise ratio. Thus, the present work is anticipated to shed light on the preparation of a library of AIE-active functionalized acrylonitriles with intriguing properties for biomedical applications.",
author = "Guangle Niu and Xiuli Zheng and Zheng Zhao and Haoke Zhang and Jianguo Wang and Xuewen He and Yuncong Chen and Xiujuan Shi and Chao Ma and Kwok, {Ryan T.K.} and Lam, {Jacky W.Y.} and Sung, {Herman H.Y.} and Williams, {Ian D.} and Wong, {Kam Sing} and Pengfei Wang and Tang, {Ben Zhong}",
note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",
year = "2019",
month = sep,
day = "25",
doi = "10.1021/jacs.9b06196",
language = "English",
volume = "141",
pages = "15111--15120",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "38",
}
Niu, G, Zheng, X, Zhao, Z, Zhang, H, Wang, J, He, X, Chen, Y, Shi, X, Ma, C, Kwok, RTK, Lam, JWY, Sung, HHY, Williams, ID, Wong, KS, Wang, P & Tang, BZ 2019, 'Functionalized Acrylonitriles with Aggregation-Induced Emission: Structure Tuning by Simple Reaction-Condition Variation, Efficient Red Emission, and Two-Photon Bioimaging', Journal of the American Chemical Society, vol. 141, no. 38, pp. 15111-15120. https://doi.org/10.1021/jacs.9b06196
Functionalized Acrylonitriles with Aggregation-Induced Emission: Structure Tuning by Simple Reaction-Condition Variation, Efficient Red Emission, and Two-Photon Bioimaging. /
Niu, Guangle; Zheng, Xiuli; Zhao, Zheng et al.
In:
Journal of the American Chemical Society, Vol. 141, No. 38, 25.09.2019, p. 15111-15120.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Functionalized Acrylonitriles with Aggregation-Induced Emission
T2 - Structure Tuning by Simple Reaction-Condition Variation, Efficient Red Emission, and Two-Photon Bioimaging
AU - Niu, Guangle
AU - Zheng, Xiuli
AU - Zhao, Zheng
AU - Zhang, Haoke
AU - Wang, Jianguo
AU - He, Xuewen
AU - Chen, Yuncong
AU - Shi, Xiujuan
AU - Ma, Chao
AU - Kwok, Ryan T.K.
AU - Lam, Jacky W.Y.
AU - Sung, Herman H.Y.
AU - Williams, Ian D.
AU - Wong, Kam Sing
AU - Wang, Pengfei
AU - Tang, Ben Zhong
N1 - Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/9/25
Y1 - 2019/9/25
N2 - Acrylonitriles with aggregation-induced emission (AIE) characteristics have been found to show promising applications in two-photon biomedical imaging. Generally, elaborate synthetic efforts are required to achieve different acrylonitriles with distinct functionalities. In this work, we first reported the synthesis of two different group-functionalized AIE-active acrylonitriles (TPAT-AN-XF and 2TPAT-AN) obtained simply by mixing the same reactants at different temperatures using a facile and transition metal-free synthetic method. These two AIE luminogens (AIEgens) exhibit unique properties such as bright red emission in the solid state, large Stokes shift, and large two-photon absorption cross section. Water-soluble nanoparticles (NPs) of 2TPAT-AN were prepared by a nanoprecipitation method. In vitro imaging data show that 2TPAT-AN NPs can selectively stain lysosome in live cells. Besides one-photon imaging, remarkable two-photon imaging of live tumor tissues can be achieved with high resolution and deep tissue penetration. 2TPAT-AN NPs show high biocompatibility and are successfully utilized in in vivo long-term imaging of mouse tumors with a high signal-to-noise ratio. Thus, the present work is anticipated to shed light on the preparation of a library of AIE-active functionalized acrylonitriles with intriguing properties for biomedical applications.
AB - Acrylonitriles with aggregation-induced emission (AIE) characteristics have been found to show promising applications in two-photon biomedical imaging. Generally, elaborate synthetic efforts are required to achieve different acrylonitriles with distinct functionalities. In this work, we first reported the synthesis of two different group-functionalized AIE-active acrylonitriles (TPAT-AN-XF and 2TPAT-AN) obtained simply by mixing the same reactants at different temperatures using a facile and transition metal-free synthetic method. These two AIE luminogens (AIEgens) exhibit unique properties such as bright red emission in the solid state, large Stokes shift, and large two-photon absorption cross section. Water-soluble nanoparticles (NPs) of 2TPAT-AN were prepared by a nanoprecipitation method. In vitro imaging data show that 2TPAT-AN NPs can selectively stain lysosome in live cells. Besides one-photon imaging, remarkable two-photon imaging of live tumor tissues can be achieved with high resolution and deep tissue penetration. 2TPAT-AN NPs show high biocompatibility and are successfully utilized in in vivo long-term imaging of mouse tumors with a high signal-to-noise ratio. Thus, the present work is anticipated to shed light on the preparation of a library of AIE-active functionalized acrylonitriles with intriguing properties for biomedical applications.
UR - http://www.scopus.com/inward/record.url?scp=85072627341&partnerID=8YFLogxK
U2 - 10.1021/jacs.9b06196
DO - 10.1021/jacs.9b06196
M3 - Article
C2 - 31436971
AN - SCOPUS:85072627341
SN - 0002-7863
VL - 141
SP - 15111
EP - 15120
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 38
ER -
Niu G, Zheng X, Zhao Z, Zhang H, Wang J, He X et al. Functionalized Acrylonitriles with Aggregation-Induced Emission: Structure Tuning by Simple Reaction-Condition Variation, Efficient Red Emission, and Two-Photon Bioimaging. Journal of the American Chemical Society. 2019 Sept 25;141(38):15111-15120. doi: 10.1021/jacs.9b06196