Abstract
A simple and unified method for the synthesis of alkylated dihydroquinolinone and pyrrolo[1,2-a]indole derivatives in moderate to high yields (up to 91%) with excellent diastereoselectivity (>20:1 dr) was developed. The inexpensive FeCl2·4H2O works as catalyst, and easily prepared peresters (or peroxides) from aliphatic acids act as alkylating reagents and single electron oxidants. This environmentally friendly reaction proceeds via an FeCl2-catalyzed alkyl radical cascade addition/cyclization fashion.
Original language | English |
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Pages (from-to) | 5149-5159 |
Number of pages | 11 |
Journal | Journal of Organic Chemistry |
Volume | 83 |
Issue number | 9 |
DOIs | |
Publication status | Published - 4 May 2018 |
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Dive into the research topics of 'FeCl2-Catalyzed Decarboxylative Radical Alkylation/Cyclization of Cinnamamides: Access to Dihydroquinolinone and Pyrrolo[1,2- a]indole Analogues'. Together they form a unique fingerprint.Cite this
Cui, Z., & Du, D. M. (2018). FeCl2-Catalyzed Decarboxylative Radical Alkylation/Cyclization of Cinnamamides: Access to Dihydroquinolinone and Pyrrolo[1,2- a]indole Analogues. Journal of Organic Chemistry, 83(9), 5149-5159. https://doi.org/10.1021/acs.joc.8b00511