Abstract
A series of readily available 2-(2-oxoindolin-3-yl)malononitriles bearing multiple active sites were first used in asymmetric catalytic synthesis, which have been successfully applied to develop a bifunctional squaramide-catalyzed cascade Michael/cyclization reaction strategy. Various cyclopentene-bispirooxindoles with three continuous stereocenters, two of which are quaternary spiro-stereocenters, were constructed in good yields with excellent stereoselectivities (up to >20:1 dr, >99% ee). (Figure presented.).
Original language | English |
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Pages (from-to) | 3387-3393 |
Number of pages | 7 |
Journal | Advanced Synthesis and Catalysis |
Volume | 361 |
Issue number | 14 |
DOIs | |
Publication status | Published - 11 Jul 2019 |
Keywords
- Bispirooxindoles
- Cascade reaction
- Michael/cyclization
- Organocatalysis
- Squaramides
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Zhao, B. L., Lin, Y., & Du, D. M. (2019). Enantioselective Construction of Bispirooxindoles via Squaramide-Catalysed Cascade Michael/Cyclization Reaction. Advanced Synthesis and Catalysis, 361(14), 3387-3393. https://doi.org/10.1002/adsc.201900358