Electrochemical DNA Biosensors Based on the Intrinsic Topological Insulator BiSbTeSe2for Potential Application in HIV Determination

Yujiu Jiang; Shanshan Li; Peng Zhu; Jinge Zhao; Xiaolu Xiong; Yetong Wu; Xu Zhang; Yongkai Li; Tinglu Song; Wende Xiao; Zhiwei Wang; Junfeng Han

doi:10.1021/acsabm.1c01153

Electrochemical DNA Biosensors Based on the Intrinsic Topological Insulator BiSbTeSe₂for Potential Application in HIV Determination

Yujiu Jiang, Shanshan Li, Peng Zhu, Jinge Zhao, Xiaolu Xiong, Yetong Wu, Xu Zhang, Yongkai Li, Tinglu Song, Wende Xiao, Zhiwei Wang^*, Junfeng Han^*

^*Corresponding author for this work

School of Physics

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

In this work, we reported a sensitive, label-free electrochemical biosensor based on the intrinsic topological insulator (TI) BiSbTeSe₂for potential application in the determination of the HIV gene. With strong spin-obit coupling, TIs could have robust surface states with low electronic noise, which might be beneficial for the stable and sensitive electron transport between the electrode and electrolyte interface. Under optimized conditions of the biosensors using BiSbTeSe₂, the differential pulse voltammetry (DPV) peak currents showed a linear relationship with the logarithm of target DNA concentrations ranging from 1.0 × 10^-13to 1.0 × 10^-7M, with a detection limit of 1.07 × 10^-15M. The sensing assay also displayed good selectivity and stability after storage at 4 °C for 7 days. This work provides an effective way to develop biosensors with topological materials, which have a potential application in the clinical determination and monitoring field.

Original language	English
Pages (from-to)	1084-1091
Number of pages	8
Journal	ACS Applied Bio Materials
Volume	5
Issue number	3
DOIs	https://doi.org/10.1021/acsabm.1c01153
Publication status	Published - 21 Mar 2022

Keywords

BiSbTeSe
differential pulse voltammetry
electrochemical biosensor
label-free
topological insulator

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Access to Document

10.1021/acsabm.1c01153

Cite this

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title = "Electrochemical DNA Biosensors Based on the Intrinsic Topological Insulator BiSbTeSe2for Potential Application in HIV Determination",

abstract = "In this work, we reported a sensitive, label-free electrochemical biosensor based on the intrinsic topological insulator (TI) BiSbTeSe2for potential application in the determination of the HIV gene. With strong spin-obit coupling, TIs could have robust surface states with low electronic noise, which might be beneficial for the stable and sensitive electron transport between the electrode and electrolyte interface. Under optimized conditions of the biosensors using BiSbTeSe2, the differential pulse voltammetry (DPV) peak currents showed a linear relationship with the logarithm of target DNA concentrations ranging from 1.0 × 10-13to 1.0 × 10-7M, with a detection limit of 1.07 × 10-15M. The sensing assay also displayed good selectivity and stability after storage at 4 °C for 7 days. This work provides an effective way to develop biosensors with topological materials, which have a potential application in the clinical determination and monitoring field.",

keywords = "BiSbTeSe, differential pulse voltammetry, electrochemical biosensor, label-free, topological insulator",

author = "Yujiu Jiang and Shanshan Li and Peng Zhu and Jinge Zhao and Xiaolu Xiong and Yetong Wu and Xu Zhang and Yongkai Li and Tinglu Song and Wende Xiao and Zhiwei Wang and Junfeng Han",

year = "2022",

month = mar,

day = "21",

doi = "10.1021/acsabm.1c01153",

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AU - Jiang, Yujiu

AU - Li, Shanshan

AU - Zhu, Peng

AU - Zhao, Jinge

AU - Xiong, Xiaolu

AU - Wu, Yetong

AU - Zhang, Xu

AU - Li, Yongkai

AU - Song, Tinglu

AU - Xiao, Wende

AU - Wang, Zhiwei

AU - Han, Junfeng

PY - 2022/3/21

Y1 - 2022/3/21

N2 - In this work, we reported a sensitive, label-free electrochemical biosensor based on the intrinsic topological insulator (TI) BiSbTeSe2for potential application in the determination of the HIV gene. With strong spin-obit coupling, TIs could have robust surface states with low electronic noise, which might be beneficial for the stable and sensitive electron transport between the electrode and electrolyte interface. Under optimized conditions of the biosensors using BiSbTeSe2, the differential pulse voltammetry (DPV) peak currents showed a linear relationship with the logarithm of target DNA concentrations ranging from 1.0 × 10-13to 1.0 × 10-7M, with a detection limit of 1.07 × 10-15M. The sensing assay also displayed good selectivity and stability after storage at 4 °C for 7 days. This work provides an effective way to develop biosensors with topological materials, which have a potential application in the clinical determination and monitoring field.

AB - In this work, we reported a sensitive, label-free electrochemical biosensor based on the intrinsic topological insulator (TI) BiSbTeSe2for potential application in the determination of the HIV gene. With strong spin-obit coupling, TIs could have robust surface states with low electronic noise, which might be beneficial for the stable and sensitive electron transport between the electrode and electrolyte interface. Under optimized conditions of the biosensors using BiSbTeSe2, the differential pulse voltammetry (DPV) peak currents showed a linear relationship with the logarithm of target DNA concentrations ranging from 1.0 × 10-13to 1.0 × 10-7M, with a detection limit of 1.07 × 10-15M. The sensing assay also displayed good selectivity and stability after storage at 4 °C for 7 days. This work provides an effective way to develop biosensors with topological materials, which have a potential application in the clinical determination and monitoring field.

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KW - differential pulse voltammetry

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