TY - JOUR
T1 - DLP 3D printing of high-resolution, temperature-responsive hydrogel microneedles with rapid customization capability
AU - Zhou, Xinmeng
AU - Liu, Huan
AU - Li, Huanjun
N1 - Publisher Copyright:
© 2024 Institute of Physics Publishing. All rights reserved.
PY - 2024
Y1 - 2024
N2 - Hydrogel microneedles (MNs) are emerging as versatile transdermal drug delivery platforms for the treatment of various diseases. However, their conventional preparation method is plagued by a complex process, time-consuming nature, and low resolution. To address these challenges, we present a novel method for preparing temperature-responsive hydrogel MNs using a Digital Light Processing (DLP) strategy. The printed NIPAM-AA-AM hydrogel MNs can be rapidly customized (within 1 hour) into various shapes and heights with high resolution. The mechanical tests and H&E staining validate the ability of the MNs to penetrate the skin. In addition, the temperature-responsive drug delivery of the MNs was demonstrated through experiments and COSMOL simulations. Notably, these biocompatible microneedles showed non-toxicity in NIH-3T3 cells and low hemolysis rates, thereby indicating promising prospects for safe in vivo utilization. This study offers a simple and rapid alternative for the fabrication of smart responsive microneedles, opening up new avenues in personalized and efficient transdermal drug delivery strategies.
AB - Hydrogel microneedles (MNs) are emerging as versatile transdermal drug delivery platforms for the treatment of various diseases. However, their conventional preparation method is plagued by a complex process, time-consuming nature, and low resolution. To address these challenges, we present a novel method for preparing temperature-responsive hydrogel MNs using a Digital Light Processing (DLP) strategy. The printed NIPAM-AA-AM hydrogel MNs can be rapidly customized (within 1 hour) into various shapes and heights with high resolution. The mechanical tests and H&E staining validate the ability of the MNs to penetrate the skin. In addition, the temperature-responsive drug delivery of the MNs was demonstrated through experiments and COSMOL simulations. Notably, these biocompatible microneedles showed non-toxicity in NIH-3T3 cells and low hemolysis rates, thereby indicating promising prospects for safe in vivo utilization. This study offers a simple and rapid alternative for the fabrication of smart responsive microneedles, opening up new avenues in personalized and efficient transdermal drug delivery strategies.
UR - http://www.scopus.com/inward/record.url?scp=85201159246&partnerID=8YFLogxK
U2 - 10.1088/1742-6596/2808/1/012041
DO - 10.1088/1742-6596/2808/1/012041
M3 - Conference article
AN - SCOPUS:85201159246
SN - 1742-6588
VL - 2808
JO - Journal of Physics: Conference Series
JF - Journal of Physics: Conference Series
IS - 1
M1 - 012041
T2 - 2024 3rd International Conference on Materials Engineering and Applied Mechanics, ICMEAAE 2024
Y2 - 15 March 2024 through 17 March 2024
ER -