TY - JOUR
T1 - Defective Ag-In-S/ZnS quantum dots
T2 - an oxygen-derived free radical scavenger for mitigating macrophage inflammation
AU - Gao, Na
AU - Jing, Jing
AU - Zhao, Hengzhi
AU - Liu, Yazhou
AU - Yang, Chunlei
AU - Gao, Mengxu
AU - Chen, Bingkun
AU - Zhang, Rubo
AU - Zhang, Xiaoling
N1 - Publisher Copyright:
© The Royal Society of Chemistry 2021.
PY - 2021/11/21
Y1 - 2021/11/21
N2 - Oxidative stress plays an important role in the development of inflammatory diseases including allergy, heart disease, diabetes and cancer. Nanomaterial-mediated antioxidant therapy is regarded as a promising strategy to treat oxidative stress-mediated inflammation. Herein, defective Ag-In-S/ZnS quantum dots (AIS/ZnS QDs) with oxygen-derived radical-scavenging capabilities are developed. Owing to their intrinsic defects and abundant surface functional groups, these quantum dots exhibit excellent oxygen-derived free radical removal efficiencyin vitro. In macrophages, AIS/ZnS QDs can eliminate intracellular excessive ROS stimulated by either H2O2or lipopolysaccharide (LPS), thus can effectively protect macrophages against ROS-induced oxidative injury. Moreover, in the model of LPS-triggered macrophage inflammation, they exhibit benign anti-inflammatory ability by inhibiting the expression of related proinflammatory cytokines (e.g., TNF-α and IL-6). These findings indicate that AIS/ZnS QDs hold great potential for the treatment of ROS-related inflammatory disorders.
AB - Oxidative stress plays an important role in the development of inflammatory diseases including allergy, heart disease, diabetes and cancer. Nanomaterial-mediated antioxidant therapy is regarded as a promising strategy to treat oxidative stress-mediated inflammation. Herein, defective Ag-In-S/ZnS quantum dots (AIS/ZnS QDs) with oxygen-derived radical-scavenging capabilities are developed. Owing to their intrinsic defects and abundant surface functional groups, these quantum dots exhibit excellent oxygen-derived free radical removal efficiencyin vitro. In macrophages, AIS/ZnS QDs can eliminate intracellular excessive ROS stimulated by either H2O2or lipopolysaccharide (LPS), thus can effectively protect macrophages against ROS-induced oxidative injury. Moreover, in the model of LPS-triggered macrophage inflammation, they exhibit benign anti-inflammatory ability by inhibiting the expression of related proinflammatory cytokines (e.g., TNF-α and IL-6). These findings indicate that AIS/ZnS QDs hold great potential for the treatment of ROS-related inflammatory disorders.
UR - http://www.scopus.com/inward/record.url?scp=85118952368&partnerID=8YFLogxK
U2 - 10.1039/d1tb01681d
DO - 10.1039/d1tb01681d
M3 - Article
C2 - 34643636
AN - SCOPUS:85118952368
SN - 2050-7518
VL - 9
SP - 8971
EP - 8979
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 43
ER -
