Abstract
Rapid construction of diverse fused-indoline−heterocycle (FIH) frameworks including high-value pyrroloindolines, furoindolines and thienoindolines in a two-step sequence has been described. The key to success hinges on the adoption of peresters as α-heteroatom alkyl radical precusors, which can smoothly react with N-arylacrylamides via a radical chain process initiated by inexpensive FeCl2⋅4H2O to afford the functionalized oxindoles, the key intermediates to FIH skeletons. The approach features operationally-simplicity, broad substrates scope and mild conditions. (Figure presented.).
Original language | English |
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Pages (from-to) | 93-99 |
Number of pages | 7 |
Journal | Advanced Synthesis and Catalysis |
Volume | 360 |
Issue number | 1 |
DOIs | |
Publication status | Published - 4 Jan 2018 |
Keywords
- Electron catalysis
- FeCl⋅4HO
- Fused-indoline−heterocycle skeletons
- Oxindoles
- Peresters
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Cui, Z., & Du, D. M. (2018). Decarboxylative Synthesis of Functionalized Oxindoles via An Iron-Initiated Radical Chain Process and Application in Constructing Diverse Fused-Indoline Heterocycles. Advanced Synthesis and Catalysis, 360(1), 93-99. https://doi.org/10.1002/adsc.201700976