Characterization of single cell dynamic morphology by local deformation pattern modeling

Heng Li, Zhiwen Liu, Fengqian Pang, Yonggang Shi

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Computational analysis of cell dynamic morphology in time-lapse images has become a new topic of biomedical research. For single cell, it is a challenging task to consider the spatial inconsistency and the temporal accumulation of cell deformation. This paper introduces an innovative automate analysis method, in which temporal features of contour point deformation are captured and then local deformation pattern is modeled to characterize cell dynamic morphology and predict cell activation statue. We applied the method to classify lymphocyte videos of multiple groups. Experimental results demonstrate that the proposed method overcomes existing methods in accuracy and robustness.

Original languageEnglish
Title of host publication2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationSmarter Technology for a Healthier World, EMBC 2017 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages329-332
Number of pages4
ISBN (Electronic)9781509028092
DOIs
Publication statusPublished - 13 Sept 2017
Event39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017 - Jeju Island, Korea, Republic of
Duration: 11 Jul 201715 Jul 2017

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Conference

Conference39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
Country/TerritoryKorea, Republic of
CityJeju Island
Period11/07/1715/07/17

Keywords

  • Cell dynamic morphology
  • Local deformation pattern
  • Temporal feature
  • Time-lapse image

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