Carboxylic silane-exchanged manganese ferrite nanoclusters with high relaxivity for magnetic resonance imaging

Yingzhe Qi; Chen Shao; Wei Gu; Fuying Li; Yunlong Deng; Hansheng Li; Ling Ye

doi:10.1039/c3tb00037k

Carboxylic silane-exchanged manganese ferrite nanoclusters with high relaxivity for magnetic resonance imaging

Yingzhe Qi, Chen Shao, Wei Gu, Fuying Li, Yunlong Deng, Hansheng Li^*, Ling Ye

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Capital Medical University

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

To improve the magnetic properties and MRI contrast effect of Fe ₃O₄ superparamagnetic nanoparticles (NPs), a series of oleate-capped, Mn-doped Mn_xFe_(1-x)Fe₂O ₄ (x ≤ 0.4) NPs was prepared via a thermal decomposition method and subsequently assembled into nanoclusters by the carboxylic silane. The effects of Mn doping and clustering on the magnetization, relaxivity and contrast enhancement of the Mn_xFe_(1-x)Fe₂O ₄ (x ≤ 0.4) NPs were studied. Our results revealed that the Mn_xFe_(1-x)Fe₂O₄ NPs exhibited the highest saturation magnetization of 82.55 emu g^-1 when x = 0.05. Correspondingly, the assembled Mn_0.05Fe_(1-0.05)Fe ₂O₄ nanoclusters showed the highest relaxivity value of 528 (Mn + Fe) mM^-1 s^-1 and an enhanced MRI contrast in mouse liver. In addition, the MTT and H&E analysis confirmed that Mn _0.05Fe_(1-0.05)Fe₂O₄ nanoclusters were non-toxic. Therefore, the biocompatible Mn_0.05Fe _(1-0.05)Fe₂O₄ nanoclusters with superior relaxometric properties hold great potential in serving as a novel MRI nanoprobe.

Original language	English
Pages (from-to)	1846-1851
Number of pages	6
Journal	Journal of Materials Chemistry B
Volume	1
Issue number	13
DOIs	https://doi.org/10.1039/c3tb00037k
Publication status	Published - 7 Apr 2013

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title = "Carboxylic silane-exchanged manganese ferrite nanoclusters with high relaxivity for magnetic resonance imaging",

abstract = "To improve the magnetic properties and MRI contrast effect of Fe 3O4 superparamagnetic nanoparticles (NPs), a series of oleate-capped, Mn-doped MnxFe(1-x)Fe2O 4 (x ≤ 0.4) NPs was prepared via a thermal decomposition method and subsequently assembled into nanoclusters by the carboxylic silane. The effects of Mn doping and clustering on the magnetization, relaxivity and contrast enhancement of the MnxFe(1-x)Fe2O 4 (x ≤ 0.4) NPs were studied. Our results revealed that the MnxFe(1-x)Fe2O4 NPs exhibited the highest saturation magnetization of 82.55 emu g-1 when x = 0.05. Correspondingly, the assembled Mn0.05Fe(1-0.05)Fe 2O4 nanoclusters showed the highest relaxivity value of 528 (Mn + Fe) mM-1 s-1 and an enhanced MRI contrast in mouse liver. In addition, the MTT and H&E analysis confirmed that Mn 0.05Fe(1-0.05)Fe2O4 nanoclusters were non-toxic. Therefore, the biocompatible Mn0.05Fe (1-0.05)Fe2O4 nanoclusters with superior relaxometric properties hold great potential in serving as a novel MRI nanoprobe.",

author = "Yingzhe Qi and Chen Shao and Wei Gu and Fuying Li and Yunlong Deng and Hansheng Li and Ling Ye",

year = "2013",

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doi = "10.1039/c3tb00037k",

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T1 - Carboxylic silane-exchanged manganese ferrite nanoclusters with high relaxivity for magnetic resonance imaging

AU - Qi, Yingzhe

AU - Shao, Chen

AU - Gu, Wei

AU - Li, Fuying

AU - Deng, Yunlong

AU - Li, Hansheng

AU - Ye, Ling

PY - 2013/4/7

Y1 - 2013/4/7

N2 - To improve the magnetic properties and MRI contrast effect of Fe 3O4 superparamagnetic nanoparticles (NPs), a series of oleate-capped, Mn-doped MnxFe(1-x)Fe2O 4 (x ≤ 0.4) NPs was prepared via a thermal decomposition method and subsequently assembled into nanoclusters by the carboxylic silane. The effects of Mn doping and clustering on the magnetization, relaxivity and contrast enhancement of the MnxFe(1-x)Fe2O 4 (x ≤ 0.4) NPs were studied. Our results revealed that the MnxFe(1-x)Fe2O4 NPs exhibited the highest saturation magnetization of 82.55 emu g-1 when x = 0.05. Correspondingly, the assembled Mn0.05Fe(1-0.05)Fe 2O4 nanoclusters showed the highest relaxivity value of 528 (Mn + Fe) mM-1 s-1 and an enhanced MRI contrast in mouse liver. In addition, the MTT and H&E analysis confirmed that Mn 0.05Fe(1-0.05)Fe2O4 nanoclusters were non-toxic. Therefore, the biocompatible Mn0.05Fe (1-0.05)Fe2O4 nanoclusters with superior relaxometric properties hold great potential in serving as a novel MRI nanoprobe.

AB - To improve the magnetic properties and MRI contrast effect of Fe 3O4 superparamagnetic nanoparticles (NPs), a series of oleate-capped, Mn-doped MnxFe(1-x)Fe2O 4 (x ≤ 0.4) NPs was prepared via a thermal decomposition method and subsequently assembled into nanoclusters by the carboxylic silane. The effects of Mn doping and clustering on the magnetization, relaxivity and contrast enhancement of the MnxFe(1-x)Fe2O 4 (x ≤ 0.4) NPs were studied. Our results revealed that the MnxFe(1-x)Fe2O4 NPs exhibited the highest saturation magnetization of 82.55 emu g-1 when x = 0.05. Correspondingly, the assembled Mn0.05Fe(1-0.05)Fe 2O4 nanoclusters showed the highest relaxivity value of 528 (Mn + Fe) mM-1 s-1 and an enhanced MRI contrast in mouse liver. In addition, the MTT and H&E analysis confirmed that Mn 0.05Fe(1-0.05)Fe2O4 nanoclusters were non-toxic. Therefore, the biocompatible Mn0.05Fe (1-0.05)Fe2O4 nanoclusters with superior relaxometric properties hold great potential in serving as a novel MRI nanoprobe.

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Carboxylic silane-exchanged manganese ferrite nanoclusters with high relaxivity for magnetic resonance imaging

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