Abstract
The water soluble 2,6-di-O-carboxymethyl-β-cyclodextrin(CM-β-CD) was used as a chiral selector to separate chloramphenicol metabolite. The effects of pH and CM-β-CD concentration on the enantiomeric separation were investigated. The addition of an organic modifier (methanol) to the buffer led to deterioration of the enantiomeric separation. The results indicated that CM-β-CD was superior to β-CD for the separation of chloramphenicol metabolite and the interaction mechanisms of CM-β-CD and β-CD were compared.
| Original language | English |
|---|---|
| Pages (from-to) | 1390 |
| Number of pages | 1 |
| Journal | Chinese Journal of Analytical Chemistry |
| Volume | 24 |
| Issue number | 12 |
| Publication status | Published - 1996 |
Keywords
- 2, 6-di-O-carboxymethyl-β-cyclodextrin
- Capillary electrophoresis
- Enantiomeric separation
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Jin, H., Li, F., Gu, J., Fu, R., Liu, Y., & Dai, R. (1996). Capillary electrophoretic enantiomeric separations with 2,6-di -O-carboxymethyl -β-cyclodextrin. Chinese Journal of Analytical Chemistry, 24(12), 1390.