Bright Aggregation-Induced Emission Nanoparticles for Two-Photon Imaging and Localized Compound Therapy of Cancers

Ying Li, Rongbing Tang, Xiaoyan Liu, Junyi Gong, Zujin Zhao, Zonghai Sheng, Jiangjiang Zhang, Xuanyu Li, Guangle Niu, Ryan T.K. Kwok, Wenfu Zheng*, Xingyu Jiang*, Ben Zhong Tang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

87 Citations (Scopus)

Abstract

Photodynamic therapy (PDT), a noninvasive therapeutic strategy for cancer treatment, which always suffers from the low reactive oxygen species (ROS) yield of traditional organic dyes. Herein, we present lipid-encapsulated aggregation-induced emission nanoparticles (AIE NPs) that have a high quantum yield (23%) and a maximum two-photon absorption (TPA) cross-section of 560 GM irradiated by near-infrared light (800 nm). The AIE NPs can serve as imaging agents for spatiotemporal imaging of tumor tissues with a penetration depth up to 505 μm on mice melanoma model. Importantly, the AIE NPs can simultaneously generate singlet oxygen (1O2) and highly toxic hydroxyl radicals (â?¢OH) upon irradiation with 800 nm irradiation for photodynamic tumor ablation. In addition, the AIE NPs can be effectively cleared from the mouse body after the imaging and therapy. This study provides a strategy to develop theranostic agents for cancer image-guided PDT with high brightness, superior photostability, and high biosafety.

Original languageEnglish
Pages (from-to)16840-16853
Number of pages14
JournalACS Nano
Volume14
Issue number12
DOIs
Publication statusPublished - 22 Dec 2020
Externally publishedYes

Keywords

  • aggregation-induced emission
  • photodynamic therapy
  • two-photon fluorescence imaging

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Li, Y., Tang, R., Liu, X., Gong, J., Zhao, Z., Sheng, Z., Zhang, J., Li, X., Niu, G., Kwok, R. T. K., Zheng, W., Jiang, X., & Tang, B. Z. (2020). Bright Aggregation-Induced Emission Nanoparticles for Two-Photon Imaging and Localized Compound Therapy of Cancers. ACS Nano, 14(12), 16840-16853. https://doi.org/10.1021/acsnano.0c05610