Asymptotic behavior for solutions to an oncolytic virotherapy model involving triply haptotactic terms

Ya nan Wei, Yifu Wang, Jing Li*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

In this paper, based on Lp- Lq estimate for the Neumann heat semigroup, we investigate the asymptotic behavior for solutions to an oncolytic virotherapy model given by {ut=Δu-ξu∇·(u∇v)-ρuuz,x∈Ω,t>0,wt=Δw-ξw∇·(w∇v)-δww+ρwuz,x∈Ω,t>0,vt=-(αuu+αww)v-δvv,x∈Ω,t>0,zt=Δz-ξz∇·(z∇v)-δzz-ρzuz+βw,x∈Ω,t>0,where u, w, v and z denote the density of uninfected cancer cells, oncolytic viruses infected cancer cells, extracellular matrix and oncolytic virus particles, respectively. It is showed that when suitably regular initial data satisfy a certain small condition, infected cancer cells and virus particle populations will both become extinct asymptotically.

Original languageEnglish
Article number55
JournalZeitschrift fur Angewandte Mathematik und Physik
Volume73
Issue number2
DOIs
Publication statusPublished - Apr 2022

Keywords

  • Asymptotic behavior
  • Lp-Lq estimation
  • Oncolytic viruses

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