Abstract
In this paper, based on Lp- Lq estimate for the Neumann heat semigroup, we investigate the asymptotic behavior for solutions to an oncolytic virotherapy model given by {ut=Δu-ξu∇·(u∇v)-ρuuz,x∈Ω,t>0,wt=Δw-ξw∇·(w∇v)-δww+ρwuz,x∈Ω,t>0,vt=-(αuu+αww)v-δvv,x∈Ω,t>0,zt=Δz-ξz∇·(z∇v)-δzz-ρzuz+βw,x∈Ω,t>0,where u, w, v and z denote the density of uninfected cancer cells, oncolytic viruses infected cancer cells, extracellular matrix and oncolytic virus particles, respectively. It is showed that when suitably regular initial data satisfy a certain small condition, infected cancer cells and virus particle populations will both become extinct asymptotically.
Original language | English |
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Article number | 55 |
Journal | Zeitschrift fur Angewandte Mathematik und Physik |
Volume | 73 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 2022 |
Keywords
- Asymptotic behavior
- Lp-Lq estimation
- Oncolytic viruses
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Wei, Y. N., Wang, Y., & Li, J. (2022). Asymptotic behavior for solutions to an oncolytic virotherapy model involving triply haptotactic terms. Zeitschrift fur Angewandte Mathematik und Physik, 73(2), Article 55. https://doi.org/10.1007/s00033-022-01691-2