TY - JOUR
T1 - Asymptotic behavior for solutions to an oncolytic virotherapy model involving triply haptotactic terms
AU - Wei, Ya nan
AU - Wang, Yifu
AU - Li, Jing
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2022/4
Y1 - 2022/4
N2 - In this paper, based on Lp- Lq estimate for the Neumann heat semigroup, we investigate the asymptotic behavior for solutions to an oncolytic virotherapy model given by {ut=Δu-ξu∇·(u∇v)-ρuuz,x∈Ω,t>0,wt=Δw-ξw∇·(w∇v)-δww+ρwuz,x∈Ω,t>0,vt=-(αuu+αww)v-δvv,x∈Ω,t>0,zt=Δz-ξz∇·(z∇v)-δzz-ρzuz+βw,x∈Ω,t>0,where u, w, v and z denote the density of uninfected cancer cells, oncolytic viruses infected cancer cells, extracellular matrix and oncolytic virus particles, respectively. It is showed that when suitably regular initial data satisfy a certain small condition, infected cancer cells and virus particle populations will both become extinct asymptotically.
AB - In this paper, based on Lp- Lq estimate for the Neumann heat semigroup, we investigate the asymptotic behavior for solutions to an oncolytic virotherapy model given by {ut=Δu-ξu∇·(u∇v)-ρuuz,x∈Ω,t>0,wt=Δw-ξw∇·(w∇v)-δww+ρwuz,x∈Ω,t>0,vt=-(αuu+αww)v-δvv,x∈Ω,t>0,zt=Δz-ξz∇·(z∇v)-δzz-ρzuz+βw,x∈Ω,t>0,where u, w, v and z denote the density of uninfected cancer cells, oncolytic viruses infected cancer cells, extracellular matrix and oncolytic virus particles, respectively. It is showed that when suitably regular initial data satisfy a certain small condition, infected cancer cells and virus particle populations will both become extinct asymptotically.
KW - Asymptotic behavior
KW - Lp-Lq estimation
KW - Oncolytic viruses
UR - http://www.scopus.com/inward/record.url?scp=85125269850&partnerID=8YFLogxK
U2 - 10.1007/s00033-022-01691-2
DO - 10.1007/s00033-022-01691-2
M3 - Article
AN - SCOPUS:85125269850
SN - 0044-2275
VL - 73
JO - Zeitschrift fur Angewandte Mathematik und Physik
JF - Zeitschrift fur Angewandte Mathematik und Physik
IS - 2
M1 - 55
ER -