Abstract
A bifunctional squaramide-catalyzed asymmetric cascade aza-Michael/Michael addition reaction for the synthesis of chiral spirothiazolidinone tetrahydroquinolines with three contiguous stereocenters has been developed. This cascade reaction proceeded well under mild conditions, and afforded the desired products in high to excellent yields (up to >99% yield) with excellent diastereoselectivities (>25:1 dr) and high enantioselectivities (up to 96% ee). More importantly, both the amplification and the derivation experiments do not affect the stereoselectivity.
Original language | English |
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Pages (from-to) | 9390-9401 |
Number of pages | 12 |
Journal | Organic and Biomolecular Chemistry |
Volume | 16 |
Issue number | 48 |
DOIs | |
Publication status | Published - 2018 |
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Song, Y. X., & Du, D. M. (2018). Asymmetric synthesis of highly functionalized spirothiazolidinone tetrahydroquinolines: Via a squaramide-catalyzed cascade reaction. Organic and Biomolecular Chemistry, 16(48), 9390-9401. https://doi.org/10.1039/c8ob02731e