TY - JOUR
T1 - Application of Carbon Ion and Its Sensitizing Agent in Cancer Therapy
T2 - A Systematic Review
AU - Wang, Xiaolin
AU - Chen, Xiaojun
AU - Li, Guangfei
AU - Han, Xiao
AU - Gao, Tianxin
AU - Liu, Weifeng
AU - Tang, Xiaoying
N1 - Publisher Copyright:
© Copyright © 2021 Wang, Chen, Li, Han, Gao, Liu and Tang.
PY - 2021/7/5
Y1 - 2021/7/5
N2 - Carbon ion radiation therapy (CIRT) is the most advanced radiation therapy (RT) available and offers new opportunities to improve cancer treatment and research. CIRT has a unique physical and biological advantage that allow them to kill tumor cells more accurately and intensively. So far, CIRT has been used in almost all types of malignant tumors, and showed good feasibility, safety and acceptable toxicity, indicating that CIRT has a wide range of development and application prospects. In addition, in order to improve the biological effect of CIRT, scientists are also trying to investigate related sensitizing agents to enhance the killing ability of tumor cells, which has attracted extensive attention. In this review, we tried to systematically review the rationale, advantages and problems, the clinical applications and the sensitizing agents of the CIRT. At the same time, the prospects of the CIRT in were prospected. We hope that this review will help researchers interested in CIRT, sensitizing agents, and radiotherapy to understand their magic more systematically and faster, and provide data reference and support for bioanalysis, clinical medicine, radiotherapy, heavy ion therapy, and nanoparticle diagnostics.
AB - Carbon ion radiation therapy (CIRT) is the most advanced radiation therapy (RT) available and offers new opportunities to improve cancer treatment and research. CIRT has a unique physical and biological advantage that allow them to kill tumor cells more accurately and intensively. So far, CIRT has been used in almost all types of malignant tumors, and showed good feasibility, safety and acceptable toxicity, indicating that CIRT has a wide range of development and application prospects. In addition, in order to improve the biological effect of CIRT, scientists are also trying to investigate related sensitizing agents to enhance the killing ability of tumor cells, which has attracted extensive attention. In this review, we tried to systematically review the rationale, advantages and problems, the clinical applications and the sensitizing agents of the CIRT. At the same time, the prospects of the CIRT in were prospected. We hope that this review will help researchers interested in CIRT, sensitizing agents, and radiotherapy to understand their magic more systematically and faster, and provide data reference and support for bioanalysis, clinical medicine, radiotherapy, heavy ion therapy, and nanoparticle diagnostics.
KW - carbon therapy
KW - clinical application
KW - heavy ion radiotherapy
KW - radiation therapy
KW - sensitizing agent
UR - http://www.scopus.com/inward/record.url?scp=85111005413&partnerID=8YFLogxK
U2 - 10.3389/fonc.2021.708724
DO - 10.3389/fonc.2021.708724
M3 - Review article
AN - SCOPUS:85111005413
SN - 2234-943X
VL - 11
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 708724
ER -
