An ultrafast responsive BODIPY-based fluorescent probe for the detection of endogenous hypochlorite in live cells

Liang Qiao; Hailiang Nie; Yulong Wu; Fangyun Xin; Congcong Gao; Jing Jing; Xiaoling Zhang

doi:10.1039/c6tb02774a

An ultrafast responsive BODIPY-based fluorescent probe for the detection of endogenous hypochlorite in live cells

Liang Qiao, Hailiang Nie, Yulong Wu, Fangyun Xin, Congcong Gao, Jing Jing^*, Xiaoling Zhang

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Hypochlorite plays a significant role in various physiological and pathological processes; however, its role is still less clear than the role of other reactive oxygen species. Herein, we report an ultrafast responsive (<0.2 s) and highly selective probe B-Ts for hypochlorite with high sensitivity and a detection limit as low as 7.5 nM. The probe was compatible in a wide pH range of 4-13. More importantly, experiments in live cells showed that the probe could penetrate the cell membrane easily and was capable of imaging endogenous and exogenous hypochlorite specifically with a fast response.

Original language	English
Pages (from-to)	525-530
Number of pages	6
Journal	Journal of Materials Chemistry B
Volume	5
Issue number	3
DOIs	https://doi.org/10.1039/c6tb02774a
Publication status	Published - 2017

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Qiao, L., Nie, H., Wu, Y., Xin, F., Gao, C., Jing, J., & Zhang, X. (2017). An ultrafast responsive BODIPY-based fluorescent probe for the detection of endogenous hypochlorite in live cells. Journal of Materials Chemistry B, 5(3), 525-530. https://doi.org/10.1039/c6tb02774a

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abstract = "Hypochlorite plays a significant role in various physiological and pathological processes; however, its role is still less clear than the role of other reactive oxygen species. Herein, we report an ultrafast responsive (<0.2 s) and highly selective probe B-Ts for hypochlorite with high sensitivity and a detection limit as low as 7.5 nM. The probe was compatible in a wide pH range of 4-13. More importantly, experiments in live cells showed that the probe could penetrate the cell membrane easily and was capable of imaging endogenous and exogenous hypochlorite specifically with a fast response.",

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AU - Qiao, Liang

AU - Nie, Hailiang

AU - Wu, Yulong

AU - Xin, Fangyun

AU - Gao, Congcong

AU - Jing, Jing

AU - Zhang, Xiaoling

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AB - Hypochlorite plays a significant role in various physiological and pathological processes; however, its role is still less clear than the role of other reactive oxygen species. Herein, we report an ultrafast responsive (<0.2 s) and highly selective probe B-Ts for hypochlorite with high sensitivity and a detection limit as low as 7.5 nM. The probe was compatible in a wide pH range of 4-13. More importantly, experiments in live cells showed that the probe could penetrate the cell membrane easily and was capable of imaging endogenous and exogenous hypochlorite specifically with a fast response.

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EP - 530

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An ultrafast responsive BODIPY-based fluorescent probe for the detection of endogenous hypochlorite in live cells

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