Abstract
Herein, we report a novel Al compound supported by a NacNac ligand that facilitates the anti-Markovnikov hydroamination of aromatic alkenes and primary amines. This represents the first instance of an aluminum-catalyzed intermolecular hydroamination of alkenes, successfully synthesizing a variety of aromatic imine derivatives. The proposed mechanism suggests that the coordination activation oftBuOK by ether solvents is crucial, allowing thetBuO− anion to coordinate with the catalyst’s Al center, thus forming a key intermediate.
Original language | English |
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Pages (from-to) | 1347-1353 |
Number of pages | 7 |
Journal | Organic and Biomolecular Chemistry |
Volume | 23 |
Issue number | 6 |
DOIs | |
Publication status | Published - 18 Dec 2024 |
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Yan, W., Ma, X., Li, Q., Pang, Z., Yang, X., Chen, Y., & Yang, Z. (2024). Aluminum-catalyzed anti-Markovnikov hydroamination of aromatic alkenes with aromatic amines. Organic and Biomolecular Chemistry, 23(6), 1347-1353. https://doi.org/10.1039/d4ob01820f