Advance and Application of Single-cell Transcriptomics in Auditory Research

Xiangyu Ma, Jiamin Guo, Mengyao Tian, Yaoyang Fu, Pei Jiang, Yuan Zhang, Renjie Chai*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Hearing loss and deafness, as a worldwide disability disease, have been troubling human beings. However, the auditory organ of the inner ear is highly heterogeneous and has a very limited number of cells, which are largely uncharacterized in depth. Recently, with the development and utilization of single-cell RNA sequencing (scRNA-seq), researchers have been able to unveil the complex and sophisticated biological mechanisms of various types of cells in the auditory organ at the single-cell level and address the challenges of cellular heterogeneity that are not resolved through by conventional bulk RNA sequencing (bulk RNA-seq). Herein, we reviewed the application of scRNA-seq technology in auditory research, with the aim of providing a reference for the development of auditory organs, the pathogenesis of hearing loss, and regenerative therapy. Prospects about spatial transcriptomic scRNA-seq, single-cell based genome, and Live-seq technology will also be discussed.

Original languageEnglish
Pages (from-to)963-980
Number of pages18
JournalNeuroscience Bulletin
Volume40
Issue number7
DOIs
Publication statusPublished - Jul 2024
Externally publishedYes

Keywords

  • Auditory sensory epithelium
  • Cochlear
  • Inner ear
  • Single-cell RNA sequencing
  • Spiral ganglion neuron

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Ma, X., Guo, J., Tian, M., Fu, Y., Jiang, P., Zhang, Y., & Chai, R. (2024). Advance and Application of Single-cell Transcriptomics in Auditory Research. Neuroscience Bulletin, 40(7), 963-980. https://doi.org/10.1007/s12264-023-01149-z