A minimally invasive in vivo electroporation method utilizing flexile electrode and microneedle roller

Dong Huang; Deyao Zhao; Jinhui Li; Lili Du; Zewen Wei; Zicai Liang; Zhihong Li

doi:10.1109/TRANSDUCERS.2017.7994389

A minimally invasive in vivo electroporation method utilizing flexile electrode and microneedle roller

Dong Huang, Deyao Zhao, Jinhui Li, Lili Du, Zewen Wei, Zicai Liang, Zhihong Li^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

9 Citations (Scopus)

Abstract

This paper reports a minimally invasive in vivo electroporation method utilizing parylene-based flexible electrode, after a treatment of microneedle device, Dermalroller^®.[1] Upon penetrating high-resistance stratum corneum, the sufficient hypodermic electric field can be established under low voltage condition. Benefiting from more uniform electric field under skin, good biocompatibility, and lower applied voltage, the transfection rate is higher and the electroporated skin is less likely to be harmed compared to the commercial device. Furthermore, the low cost and convenient operation offer vast potential for clinical applications.

Original language	English
Title of host publication	TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1684-1687
Number of pages	4
ISBN (Electronic)	9781538627310
DOIs	https://doi.org/10.1109/TRANSDUCERS.2017.7994389
Publication status	Published - 26 Jul 2017
Externally published	Yes
Event	19th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2017 - Kaohsiung, Taiwan, Province of China Duration: 18 Jun 2017 → 22 Jun 2017

Publication series

Name	TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems

Conference

Conference	19th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2017
Country/Territory	Taiwan, Province of China
City	Kaohsiung
Period	18/06/17 → 22/06/17

Keywords

Flexible electrode
In vivo electroporation
Microneedle roller
Minimally invasive

Access to Document

10.1109/TRANSDUCERS.2017.7994389

Cite this

Huang, D., Zhao, D., Li, J., Du, L., Wei, Z., Liang, Z., & Li, Z. (2017). A minimally invasive in vivo electroporation method utilizing flexile electrode and microneedle roller. In TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 1684-1687). Article 7994389 (TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2017.7994389

Huang, Dong ; Zhao, Deyao ; Li, Jinhui et al. / A minimally invasive in vivo electroporation method utilizing flexile electrode and microneedle roller. TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems. Institute of Electrical and Electronics Engineers Inc., 2017. pp. 1684-1687 (TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems).

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title = "A minimally invasive in vivo electroporation method utilizing flexile electrode and microneedle roller",

abstract = "This paper reports a minimally invasive in vivo electroporation method utilizing parylene-based flexible electrode, after a treatment of microneedle device, Dermalroller{\textregistered}.[1] Upon penetrating high-resistance stratum corneum, the sufficient hypodermic electric field can be established under low voltage condition. Benefiting from more uniform electric field under skin, good biocompatibility, and lower applied voltage, the transfection rate is higher and the electroporated skin is less likely to be harmed compared to the commercial device. Furthermore, the low cost and convenient operation offer vast potential for clinical applications.",

keywords = "Flexible electrode, In vivo electroporation, Microneedle roller, Minimally invasive",

author = "Dong Huang and Deyao Zhao and Jinhui Li and Lili Du and Zewen Wei and Zicai Liang and Zhihong Li",

note = "Publisher Copyright: {\textcopyright} 2017 IEEE.; 19th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2017 ; Conference date: 18-06-2017 Through 22-06-2017",

year = "2017",

month = jul,

day = "26",

doi = "10.1109/TRANSDUCERS.2017.7994389",

language = "English",

series = "TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "1684--1687",

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address = "United States",

}

Huang, D, Zhao, D, Li, J, Du, L, Wei, Z, Liang, Z & Li, Z 2017, A minimally invasive in vivo electroporation method utilizing flexile electrode and microneedle roller. in TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems., 7994389, TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems, Institute of Electrical and Electronics Engineers Inc., pp. 1684-1687, 19th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2017, Kaohsiung, Taiwan, Province of China, 18/06/17. https://doi.org/10.1109/TRANSDUCERS.2017.7994389

A minimally invasive in vivo electroporation method utilizing flexile electrode and microneedle roller. / Huang, Dong; Zhao, Deyao; Li, Jinhui et al.
TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems. Institute of Electrical and Electronics Engineers Inc., 2017. p. 1684-1687 7994389 (TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - A minimally invasive in vivo electroporation method utilizing flexile electrode and microneedle roller

AU - Huang, Dong

AU - Zhao, Deyao

AU - Li, Jinhui

AU - Du, Lili

AU - Wei, Zewen

AU - Liang, Zicai

AU - Li, Zhihong

PY - 2017/7/26

Y1 - 2017/7/26

N2 - This paper reports a minimally invasive in vivo electroporation method utilizing parylene-based flexible electrode, after a treatment of microneedle device, Dermalroller®.[1] Upon penetrating high-resistance stratum corneum, the sufficient hypodermic electric field can be established under low voltage condition. Benefiting from more uniform electric field under skin, good biocompatibility, and lower applied voltage, the transfection rate is higher and the electroporated skin is less likely to be harmed compared to the commercial device. Furthermore, the low cost and convenient operation offer vast potential for clinical applications.

AB - This paper reports a minimally invasive in vivo electroporation method utilizing parylene-based flexible electrode, after a treatment of microneedle device, Dermalroller®.[1] Upon penetrating high-resistance stratum corneum, the sufficient hypodermic electric field can be established under low voltage condition. Benefiting from more uniform electric field under skin, good biocompatibility, and lower applied voltage, the transfection rate is higher and the electroporated skin is less likely to be harmed compared to the commercial device. Furthermore, the low cost and convenient operation offer vast potential for clinical applications.

KW - Flexible electrode

KW - In vivo electroporation

KW - Microneedle roller

KW - Minimally invasive

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DO - 10.1109/TRANSDUCERS.2017.7994389

M3 - Conference contribution

AN - SCOPUS:85029350642

T3 - TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems

SP - 1684

EP - 1687

BT - TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2017

Y2 - 18 June 2017 through 22 June 2017

ER -

Huang D, Zhao D, Li J, Du L, Wei Z, Liang Z et al. A minimally invasive in vivo electroporation method utilizing flexile electrode and microneedle roller. In TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems. Institute of Electrical and Electronics Engineers Inc. 2017. p. 1684-1687. 7994389. (TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems). doi: 10.1109/TRANSDUCERS.2017.7994389

A minimally invasive in vivo electroporation method utilizing flexile electrode and microneedle roller

Abstract

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Keywords

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