Abstract
Based on the fact that hydrogen sulfide (H2S) possesses the smallest steric hindrance among thiols and the SH- group adds faster to an electron-poor CC double bond, we designed and synthesized a tricyanoethylene-derived colorimetric chemodosimeter 1 for the fast and highly selective assay of H2S. Chemodosimeter 1 exhibited excellent water-solubility due to the introduction of two hydrophilic hydroxyl groups. Upon the addition of Na2S, chemodosimeter 1 showed a fast (complete within 400 s) and robust decrease of the absorption intensity (>97%), accompanied by a color change from red to colorless. Additionally, a linear relationship between absorption intensity and the added Na2S concentrations (0-130 μM) was observed in aqueous buffer solution (pH 7.4, 20 mM PBS). Importantly, the proposed paradigm in this paper, adoption of the tricyanoethylene derivative as a recognition receptor to distinguish H 2S from other thiols and analytes, provides a promising methodology for the design of colorimetric and fluorescent chemodosimeters for fast determination of H2S.
Original language | English |
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Pages (from-to) | 5576-5580 |
Number of pages | 5 |
Journal | The Analyst |
Volume | 137 |
Issue number | 23 |
DOIs | |
Publication status | Published - 2012 |