Abstract
An efficient highly diastereo- and enantioselective protocol to access optically pure fluorine-containing 2-amino-cyclopenta[b]pyran derivatives using Lewis acid catalysis and organocatalysis sequence has been developed. The corresponding products could be obtained in good to excellent yields with good to excellent diastereoselectivity and enantioselectivity (up to 99:1 dr, >99% ee).
Original language | English |
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Pages (from-to) | 3639-3647 |
Number of pages | 9 |
Journal | Advanced Synthesis and Catalysis |
Volume | 357 |
Issue number | 16-17 |
DOIs | |
Publication status | Published - 16 Nov 2015 |
Keywords
- Michael addition
- asymmetric catalysis
- bis(thiazolines)
- fluorination
- pyrans
- squaramides
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Peng, J., Zhao, B. L., & Du, D. M. (2015). A Combination of Metal and Organic Catalysis: Highly Diastereo- and Enantioselective Construction of Fluorinated 2-Aminocyclopenta[b]pyran Derivatives. Advanced Synthesis and Catalysis, 357(16-17), 3639-3647. https://doi.org/10.1002/adsc.201500744