A colorimetric and ratiometric fluorescent probe for quantitative detection of GSH at physiologically relevant levels

Xiaodan Zeng; Xiaoling Zhang; Baocun Zhu; Hongying Jia; Wen Yang; Yamin Li; Juan Xue

doi:10.1016/j.snb.2011.06.062

A colorimetric and ratiometric fluorescent probe for quantitative detection of GSH at physiologically relevant levels

Xiaodan Zeng, Xiaoling Zhang^*, Baocun Zhu, Hongying Jia, Wen Yang, Yamin Li, Juan Xue

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

A naphthalene derivate containing piazselenole (NDP) has been developed as an example of colorimetric and ratiometric fluorescent probes for glutathione (GSH) at physiologically relevant concentration. Upon addition of GSH, the probe displayed a ratiometric fluorescent response with an enhancement of the ratios of emission intensities at 436 and 615 nm, accompanied with the solution color change from jacinth to colorlessness. The detection range is 0-80 mM with the detection limit of 0.178 mM. Moreover, the probe showed good selectivity and satisfying results in the determination of GSH. As the linear response range covers the concentration range of biological samples, the probe may have the potential to determine GSH directly in biological samples in the future.

Original language	English
Pages (from-to)	142-147
Number of pages	6
Journal	Sensors and Actuators, B: Chemical
Volume	159
Issue number	1
DOIs	https://doi.org/10.1016/j.snb.2011.06.062
Publication status	Published - 28 Nov 2011

Keywords

Colorimetric
Glutathione (GSH)
Piazselenole
Probe
Ratiometric fluorescent

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10.1016/j.snb.2011.06.062

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abstract = "A naphthalene derivate containing piazselenole (NDP) has been developed as an example of colorimetric and ratiometric fluorescent probes for glutathione (GSH) at physiologically relevant concentration. Upon addition of GSH, the probe displayed a ratiometric fluorescent response with an enhancement of the ratios of emission intensities at 436 and 615 nm, accompanied with the solution color change from jacinth to colorlessness. The detection range is 0-80 mM with the detection limit of 0.178 mM. Moreover, the probe showed good selectivity and satisfying results in the determination of GSH. As the linear response range covers the concentration range of biological samples, the probe may have the potential to determine GSH directly in biological samples in the future.",

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T1 - A colorimetric and ratiometric fluorescent probe for quantitative detection of GSH at physiologically relevant levels

AU - Zeng, Xiaodan

AU - Zhang, Xiaoling

AU - Zhu, Baocun

AU - Jia, Hongying

AU - Yang, Wen

AU - Li, Yamin

AU - Xue, Juan

PY - 2011/11/28

Y1 - 2011/11/28

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AB - A naphthalene derivate containing piazselenole (NDP) has been developed as an example of colorimetric and ratiometric fluorescent probes for glutathione (GSH) at physiologically relevant concentration. Upon addition of GSH, the probe displayed a ratiometric fluorescent response with an enhancement of the ratios of emission intensities at 436 and 615 nm, accompanied with the solution color change from jacinth to colorlessness. The detection range is 0-80 mM with the detection limit of 0.178 mM. Moreover, the probe showed good selectivity and satisfying results in the determination of GSH. As the linear response range covers the concentration range of biological samples, the probe may have the potential to determine GSH directly in biological samples in the future.

KW - Colorimetric

KW - Glutathione (GSH)

KW - Piazselenole

KW - Probe

KW - Ratiometric fluorescent

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A colorimetric and ratiometric fluorescent probe for quantitative detection of GSH at physiologically relevant levels

Abstract

Keywords

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