无溶剂体系介孔分子筛 SBA-15 固定化脂肪酶拆分(R,S)-3-氯-1-苯基丙醇

Da Zhang Dai; Wen Ting Jiang; Lu Yang Xu

doi:10.16084/j.issn1001-3555.2023.04.003

无溶剂体系介孔分子筛 SBA-15 固定化脂肪酶拆分(R,S)-3-氯-1-苯基丙醇

Translated title of the contribution: Resolution of (R,S)-3-Chloro-1-phenylpropanol by Mesoporous Molecular Sieve SBA-15 Immobilized Lipase in Solvent-Free System

Da Zhang Dai^*, Wen Ting Jiang, Lu Yang Xu

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

In solvent-free reaction system, the resolution of (R,S)-3-chloro-1-phenylpropanol was performed by P. fluorescens lipase (PFL) immobilized into Mesoporous molecular sieve SBA-15. It was found that conversion (c) of the enzymatic resolution reached 49.87%, and enantiomeric excess for the product (ee_p) reached 98.73%, under the optimized conditions of using vinyl acetate as acyl donor, water activity 0.19, “memory” pH 7.0, 60 ℃ for 28 h in solvent-free system, presenting a good promise in the enzymatic resolution of (R,S)- 3-chloro-1-phenylpropanol.

Translated title of the contribution	Resolution of (R,S)-3-Chloro-1-phenylpropanol by Mesoporous Molecular Sieve SBA-15 Immobilized Lipase in Solvent-Free System
Original language	Chinese (Traditional)
Pages (from-to)	342-347
Number of pages	6
Journal	Journal of Molecular Catalysis
Volume	37
Issue number	4
DOIs	https://doi.org/10.16084/j.issn1001-3555.2023.04.003
Publication status	Published - Aug 2023

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title = "无溶剂体系介孔分子筛 SBA-15 固定化脂肪酶拆分(R,S)-3-氯-1-苯基丙醇",

abstract = "In solvent-free reaction system, the resolution of (R,S)-3-chloro-1-phenylpropanol was performed by P. fluorescens lipase (PFL) immobilized into Mesoporous molecular sieve SBA-15. It was found that conversion (c) of the enzymatic resolution reached 49.87%, and enantiomeric excess for the product (eep) reached 98.73%, under the optimized conditions of using vinyl acetate as acyl donor, water activity 0.19, “memory” pH 7.0, 60 ℃ for 28 h in solvent-free system, presenting a good promise in the enzymatic resolution of (R,S)- 3-chloro-1-phenylpropanol.",

keywords = "3-chloro-1-phenylpropanol, immobilized lipase, mesoporous molecular sieve, resolution, solvent-free system",

author = "Dai, {Da Zhang} and Jiang, {Wen Ting} and Xu, {Lu Yang}",

year = "2023",

month = aug,

doi = "10.16084/j.issn1001-3555.2023.04.003",

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AU - Dai, Da Zhang

AU - Jiang, Wen Ting

AU - Xu, Lu Yang

PY - 2023/8

Y1 - 2023/8

N2 - In solvent-free reaction system, the resolution of (R,S)-3-chloro-1-phenylpropanol was performed by P. fluorescens lipase (PFL) immobilized into Mesoporous molecular sieve SBA-15. It was found that conversion (c) of the enzymatic resolution reached 49.87%, and enantiomeric excess for the product (eep) reached 98.73%, under the optimized conditions of using vinyl acetate as acyl donor, water activity 0.19, “memory” pH 7.0, 60 ℃ for 28 h in solvent-free system, presenting a good promise in the enzymatic resolution of (R,S)- 3-chloro-1-phenylpropanol.

AB - In solvent-free reaction system, the resolution of (R,S)-3-chloro-1-phenylpropanol was performed by P. fluorescens lipase (PFL) immobilized into Mesoporous molecular sieve SBA-15. It was found that conversion (c) of the enzymatic resolution reached 49.87%, and enantiomeric excess for the product (eep) reached 98.73%, under the optimized conditions of using vinyl acetate as acyl donor, water activity 0.19, “memory” pH 7.0, 60 ℃ for 28 h in solvent-free system, presenting a good promise in the enzymatic resolution of (R,S)- 3-chloro-1-phenylpropanol.

KW - 3-chloro-1-phenylpropanol

KW - immobilized lipase

KW - mesoporous molecular sieve

KW - resolution

KW - solvent-free system

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DO - 10.16084/j.issn1001-3555.2023.04.003

M3 - 文章

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无溶剂体系介孔分子筛 SBA-15 固定化脂肪酶拆分(R,S)-3-氯-1-苯基丙醇

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