Abstract
Nucleus probes for real - time imaging of DNA in live cells are very rare. Herein, the combined use of Ru(N^N)3, Ir(C^N)2(N^N), Re(CO)3Cl(N^N), and Pt(C^N)(N^N) produced four heterobimetallic complexes. Two different functional metal sites are arranged at both ends of linear bis-chelating linkers (N^N)-(N^N), leading to asymmetric dumbbell-like molecules M1-M2, namely, Ru-Re, Ru-Pt, Ir-Re, and Ir-Pt. The red emissive probes of Ru-Re and Ru-Pt offer the benefits of large Stokes shift, excellent nucleus membrane penetration, and DNA binding ability with good photostability. Moreover, DNA imaging of Ru-Re and Ru-Pt probes was comparable to the commercial dye of Hoechst 33342 which is specially used for staining DNA in the nucleus of live cells. However, the Ir-based probes of Ir-Re and Ir-Pt directly targeted mitochondria. The emission properties and selective intracellular localizations of different probes are highly dependent on the metal species used in the heterobimetallic complexes.
| Translated title of the contribution | Luminescent heterobimetallic probes for selectively locating DNA in the nucleus and mitochondria of live cells |
|---|---|
| Original language | Chinese (Traditional) |
| Pages (from-to) | 1463-1470 |
| Number of pages | 8 |
| Journal | Chinese Journal of Inorganic Chemistry |
| Volume | 39 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2023 |