Abstract
The biocatalytic desymmetrization of racemates of chiral compounds is the focus, difficulty and hotspot in the field of biological and organic synthesis currently, and it is also an important way to prepare optically pure chiral compounds. In this paper, the methods for biocatalytic desymmetrization of chiral compounds developed in recent years are summarized as desymmetrization by stereoinversion, linear desymmetrization, cyclic desymmetrization, enantioconvergent process desymmetrization and one-step desymmetrization. The principles, characteristics and application progress of these methods are respectively introduced and their future development trends are prospected.
| Translated title of the contribution | Research Progress in Biocatalytic Desymmetrization of Racemic Compounds |
|---|---|
| Original language | Chinese (Traditional) |
| Pages (from-to) | 471-483 |
| Number of pages | 13 |
| Journal | Journal of Molecular Catalysis |
| Volume | 35 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 2021 |