Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake

Jiashu Sun, Lu Zhang, Jiuling Wang, Qiang Feng, Dingbin Liu, Qifang Yin, Dongyan Xu, Yujie Wei, Baoquan Ding, Xinghua Shi*, Xingyu Jiang

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

406 引用 (Scopus)

摘要

Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more-rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity-dependent cellular uptake is revealed through atomistic-level simulations.

源语言英语
页(从-至)1402-1407
页数6
期刊Advanced Materials
27
8
DOI
出版状态已出版 - 25 2月 2015
已对外发布

指纹

探究 'Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake' 的科研主题。它们共同构成独一无二的指纹。

引用此